ArticleScientific reports2025
Modifiable lifestyle factors and genetic risk of obesity in Indians.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
This study investigates whether sustained adherence to a healthy lifestyle is associated with lower obesity risk among individuals of Indian ancestry who have a high polygenic risk score (PRS) for body mass index (BMI). For the purposes of this research, a health-promoting lifestyle is defined by routine physical activity, non-smoking or minimal smoking behavior, and adherence to a balanced diet. We analyzed two independent cohorts: 6,663 Indian participants from the UK Biobank and 91 participants from the Wellytics-Asian Institute of Gastroenterology cohort. Genetic predisposition was quantified using a BMI-PRS, while lifestyle behaviors were combined into a composite score categorized as favorable or unfavorable. Obese individuals exhibited significantly higher PRS values than non-obese counterparts (UKB: P = 1.3 × 10^-85; W-AIG: P = 6.67 × 10
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