ArticleNPJ systems biology and applications2025
Criticality and increased intrinsic neural timescales in stroke.
Article in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Immediate to longer-term neurophysiological impact of acute neural network disruption.medRxiv : the preprint server for health sciences · 2026Article
- Attenuated sensorimotor hemodynamic responses and altered cortical dynamics during passive proprioceptive-related stimulation after stroke: a multidimensional fNIRS study.Frontiers in neurology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Stroke disrupts brain function beyond focal lesions, altering multiscale temporal dynamics essential for information processing. We investigated intrinsic neural timescales (INT) and other properties of long-range temporal correlations, using longitudinal fMRI data from 15 ischemic stroke patients across 6 months, and compared them to age-matched controls. Results show that stroke patients exhibited significantly prolonged INT in multiple cortical regions, reflecting slowed temporal dynamics and disrupted hierarchy. These dynamic changes persisted through recovery and were more pronounced in patients with poor outcomes, especially within cognitive control networks. Computational modeling suggested that stroke-induced INT prolongation driven by heightened neuronal excitability reflects a dynamic shift towards criticality. Our findings position long-range temporal correlations and INT as potential biomarkers for monitoring and predicting functional recovery. This framework provides a novel perspective on stroke-induced brain changes and suggests avenues for targeted neurorehabilitation using interventions aiming at restoring intrinsic temporal dynamics.
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Registered trials
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