Evidence map›Paper›PMID 41354661›Full record

ArticleNature communications2025

Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors.

Alexandre Laliberté, Caterina Prelli Bozzo, Dhiraj Acharya, Aurora De Luna, Maximilian Hirschenberger, Junji Zhu, Meta Volcic, Bettina Stolp, Cristina M Rodriguez-Quinteros, Oliver T Fackler and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandre Laliberté *Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.ORCID http://orcid.org/0000-0002-6526-4133
Caterina Prelli Bozzo *Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Dhiraj AcharyaFlorida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, USA.
Aurora De LunaInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.ORCID http://orcid.org/0009-0008-0214-4872
Maximilian HirschenbergerInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.ORCID http://orcid.org/0000-0001-8766-1271
Junji ZhuFlorida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, USA.ORCID http://orcid.org/0000-0003-2968-180X
Meta VolcicInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.ORCID http://orcid.org/0000-0001-6406-7683
Bettina StolpDepartment of Infectious Diseases, Integrative Virology, CIID, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Cristina M Rodriguez-QuinterosDepartment of Infectious Diseases, Integrative Virology, CIID, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Oliver T FacklerDepartment of Infectious Diseases, Integrative Virology, CIID, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2982-4209
Michaela U GackFlorida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, USA.ORCID http://orcid.org/0000-0002-2163-2598
Konstantin M J SparrerInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Konstantin.Sparrer@uni-ulm.de.ORCID http://orcid.org/0000-0002-8682-1779
Frank KirchhoffInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. Frank.Kirchhoff@uni-ulm.de.ORCID http://orcid.org/0000-0002-7052-2360

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) CRC1279, CRC1507Deutsche Forschungsgemeinschaft (German Research Foundation) CRC 1279, SP 1600/7-1, SP 1600/9-1Deutsche Forschungsgemeinschaft (German Research Foundation) FA 378/27-1EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) Traitor viruses
6 · The paper itself

Abstract

Sensing of viral pathogens by RIG-I-like receptors (RLRs) requires their priming via dephosphorylation mediated by the protein phosphatase 1 regulatory subunit 12 C (R12C), which is activated upon virus-induced actin rearrangements. Here, we show that the HIV-1 accessory protein Nef prevents R12C-mediated RLR priming, thereby suppressing viral sensing. HIV-1 variants containing single point mutations in Nef (F/R191A) that ablate its ability to bind the actin-modulating kinase PAK2 trigger increased interferon (IFN) responses in primary CD4

Indexed as

ActinsDEAD Box Protein 58HIV-1HIV Infectionsnef Gene Products, Human Immunodeficiency VirusCD4-Positive T-LymphocytesDendritic CellsHEK293 CellsHumansImmunity, InnateInterferon-Induced Helicase, IFIH1InterferonsMacrophagesp21-Activated KinasesPhosphorylationProtein Phosphatase 1ActinsDEAD Box Protein 58IFIH1 protein, humanInterferon-Induced Helicase, IFIH1Interferonsnef Gene Products, Human Immunodeficiency Virusnef protein, Human immunodeficiency virus 1p21-Activated KinasesPAK2 protein, humanProtein Phosphatase 1Receptors, ImmunologicRIGI protein, human

Identifiers

PMID41354661
PMCPMC12686415

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.