Evidence map›Paper›PMID 41354636›Full record

ArticleEuropean journal of haematology2026

Pubertal Assessment and Growth in Patients With Hemoglobinopathies: A Longitudinal Multicenter Study on the Association With Ferritin Levels.

J Dülberg, C Sanchez, M-A Burckhardt, L Alacán Friedrich, V Salow, A Radauer-Plank, A Borgmann-Staudt, H Cario, M Diepold, B Drexler and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

J DülbergFaculty of Medicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0008-1106-5754
C SanchezPediatric Research Centre, University Children's Hospital Basel, University of Basel, Basel, Switzerland.
M-A BurckhardtPediatric Endocrinology and Diabetology, University Children's Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-6274-5900
L Alacán FriedrichDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
V SalowDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
A Radauer-PlankDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
A Borgmann-StaudtDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
H CarioDepartment of Pediatrics and Adolescent Medicine, University Medical Centre Ulm, Ulm, Germany.
M DiepoldDivision of Pediatric Hematology and Oncology, Children's Hospital Inselspital Bern, Bern, Switzerland.
B DrexlerDivision of Hematology, University Hospital Basel, Basel, Switzerland.
L InfantiDivision of Hematology, University Hospital Basel, Basel, Switzerland.
S KroissDepartment of Pediatric Hematology and Oncology, University Children's Hospital Zurich, Zurich, Switzerland.
N DietlikerDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
R MerkiDivision of Hematology, Kantonsspital Luzern, Lucerne, Switzerland.
L NjueDivision of Hematology, Inselspital Bern, Bern, Switzerland.
L OevermannDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
A RovóDivision of Hematology, Inselspital Bern, Bern, Switzerland.
K ScheinemannDivision of Pediatric Hematology and Oncology, Ostschweizer Kinderspital, St. Gallen, Switzerland.
M SchneiderDepartment of Pediatrics, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria.
M BalcerekDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
T Diesch-FurlanettoDivision of Pediatric Hematology and Oncology, University Children's Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-0018-3447

Funding

Berlin Institute of HealthGottfried und Julia Bangerter-Rhyner-StiftungStiftung für Hämatologische Forschung Basel
6 · The paper itself

Abstract

objectivesAlthough Advancements in the Treatment of Hemoglobinopathies have Considerably Increased Life Expectancy, Hormonal and Pubertal Development Have Been Continuously Affected by Complications From Transfusion-Related Iron Overload and Cytotoxic Therapies. This Study Investigated the Association Between Serum Ferritin Levels and Pubertal Progression in Patients With Thalassemia and Sickle Cell Disease (SCD).

methodsData Collected From 10 Hospitals in Austria, Germany, and Switzerland From 2012 to 2020 Were Retrospectively Analyzed. We Enrolled 140 Individuals (Median Age: 16.5 Years) With Thalassemia or SCD.

resultsOverall, Delayed Puberty Was Observed in 14.7% (6.7% Females; 21.1% Males) and 13.2% of Patients With Thalassemia and SCD (6.9% Females; 20.8% Males), respectively. Gonadal Insufficiency Was Found in 13.3% and 8.6% of Females With Thalassemia and SCD, Respectively. Abnormal Growth Trajectories Were Observed in 32.5% (28.5% Females; 36.8% Males) and 18.7% of Patients With Thalassemia and SCD (13.3% Females; 23.5% Males), respectively. A Statistically Significant Association Was Found Between Elevated Ferritin Levels and Growth Delays in Patients With Thalassemia. Notably, Tanner Staging Data Were Missing in 80.7% of the Medical Records.

conclusionsOur Results Indicated the Need for Comprehensive Pubertal Screening and Underscored the Importance of Robust Endocrine Follow-Up Care in Individuals With Hemoglobinopathies.

Indexed as

FerritinsHemoglobinopathiesPubertyAdolescentAdultBiomarkersChildFemaleHumansLongitudinal StudiesMaleRetrospective StudiesYoung AdultBiomarkersFerritinschronic transfusionhemoglobinopathiesiron overloadpuberty

Identifiers

PMID41354636
PMCPMC12861717

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