Evidence map›Paper›PMID 41354626›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Uncoupling Metastasis and Epithelial-to-Mesenchymal Transition in sgP19/kRAS-Driven Spontaneous Metastatic Liver Tumor Model.

Jingwen Wang, Zijing Xu, Lei Xu, Lishan Wang, Jiahao Geng, Xue Wang, Meng Xu, Daphne Superville, Melissa Reeves, Matthias Evert and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jingwen WangSchool of Traditional Chinese Medicine, Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Zijing XuSchool of Traditional Chinese Medicine, Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Lei XuDepartment of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, 210008, P. R. China.
Lishan WangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210008, P. R. China.
Jiahao GengSchool of Traditional Chinese Medicine, Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Xue WangCancer Biology Program, University of Hawai'i Cancer Center, University of Hawai'i, Honolulu, Hawaii, HI 96813, USA.
Meng XuDepartment of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xian, Shaanxi Province, 710004, P. R. China.
Daphne SupervilleDepartment of Cell and Tissue Biology, UCSF, San Francisco, CA, CA 94143, USA.
Melissa ReevesHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, UT 84112, USA.
Matthias EvertInstitute of Pathology, University of Regensburg, 93053, Regensburg, Germany.
Diego F CalvisiDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, Sassari, 07100, Italy.
Xin ChenCancer Biology Program, University of Hawai'i Cancer Center, University of Hawai'i, Honolulu, Hawaii, HI 96813, USA.ORCID https://orcid.org/0000-0002-9588-0164
Xinhua SongSchool of Traditional Chinese Medicine, Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.

Funding

Investigating Multifactorial Beta-catenin Activation in Hepatocellular CancersR01CA250227 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Xin Chen, Satdarshan Singh Monga · 2021 to 2026
$3.0M
Signaling pathways during hepatocarcinogenesisR01CA239251 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CHEN, XIN · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA239251NCI NIH HHS R01 CA250227
6 · The paper itself

Abstract

Epithelial-to-mesenchymal transition (EMT) is an early event during tumor metastasis. Here, the relevance of EMT in liver carcinogenesis and metastasis is sought to be determined in a murine mixed typical intrahepatic cholangiocarcinoma (iCCA)/sarcomatoid iCCA liver tumor model using CRISPR/Cas9-based gene deletion of p19 (sgP19) in combination with transposon-based expression of the activated form of pCaggs-kRAS

Indexed as

CholangiocarcinomaEpithelial-Mesenchymal TransitionLiver NeoplasmsAnimalsDisease Models, AnimalMiceNeoplasm Metastasisepithelial‐to‐mesenchymal transitionintrahepatic cholangiocarcinomametastasisTGFβZEB1

Identifiers

PMID41354626
PMCPMC12884727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.