Evidence map›Paper›PMID 41354148›Full record

ArticleJournal of molecular biology2026

The Nuclease Domain of E. coli RecBCD Helicase Regulates DNA Binding and Base Pair Melting.

Linxuan Hao, Rui Zhang, Timothy M Lohman

Abstract read
In one paragraph

Article in Journal of molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Linxuan HaoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8231, Saint Louis, MO 63110, United States.
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8231, Saint Louis, MO 63110, United States.
Timothy M LohmanDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8231, Saint Louis, MO 63110, United States. Electronic address: lohman@wustl.edu.

Funding

HELICASE-CATALYZED DNA UNWINDINGR01GM045948 · NIGMS · WASHINGTON UNIVERSITY · PI LOHMAN, TIMOTHY M · 1991 to 2020
$9.2M
Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome MaintenanceR35GM136632 · NIGMS · WASHINGTON UNIVERSITY · PI Timothy M Lohman · 2020 to 2026
$5.5M
NIGMS NIH HHS R01 GM045948NIGMS NIH HHS R35 GM136632
6 · The paper itself

Abstract

E. coli RecBCD, a hetero-trimeric helicase and nuclease, functions in double stranded (ds) DNA break repair. RecBCD possesses ATPase motor domains within both RecB (3'-5') and RecD (5'-3') and a nuclease domain within RecB (RecB

Indexed as

DNA, BacterialEscherichia coliEscherichia coli ProteinsExodeoxyribonuclease VBase PairingBinding SitesDNADNA HelicasesModels, MolecularNucleic Acid DenaturationProtein BindingProtein DomainsThermodynamicsDNADNA, BacterialDNA HelicasesEscherichia coli ProteinsExodeoxyribonuclease Vexodeoxyribonuclease V, E coliallosteric regulationcryo-EMDNA recombinationSF1 helicasethermodynamics

Identifiers

PMID41354148
PMCPMC13101046

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.