Evidence map›Paper›PMID 41353774›Full record

ArticleOral diseases2026

Inflammatory Cytokine Changes in Herpes Simplex Virus Infected Periodontium: An In Vitro Proteomic Study.

Yu Zhang, Ka-Lam Lo, Chun-Mei Wang, Xi-Ping Feng, Jing Ni, Xi Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu ZhangDepartment of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0003-0401-3768
Ka-Lam LoDepartment of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.ORCID https://orcid.org/0009-0004-2527-868X
Chun-Mei WangShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, People's Republic of China.
Xi-Ping FengDepartment of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-4587-6394
Jing NiDepartment of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.
Xi ChenDepartment of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0003-2647-7926

Funding

Shanghai Municipal Health CommissionShanghai Ninth People's Hospital Physicians in Clinical Research Training Program
6 · The paper itself

Abstract

objectivePeriodontitis is the primary cause of tooth loss worldwide. This study aimed to identify herpes simplex virus (HSV) related biomarkers in periodontitis patients.

methodsThe present study used DIA-based liquid chromatography-tandem mass spectrometry to analyze the proteome of human gingival fibroblasts (HGFs) from one healthy donor across early and late stages (12-72 h) of HSV-1 infection.

resultsThe study identified 890 differentially expressed proteins. At the early infection stage, there was a notable upregulation of proteins including interferon (IFN) regulatory factor 7, IFN-stimulated genes 15, interleukin 6 (IL6), toll-like receptor 2 (TLR2), and IFN-induced protein (IFI), alongside a downregulation of matrix metalloproteinase 2 (MMP2). We observed the activation of pathways, including the complement and coagulation cascades, lysosome, nucleotide-binding oligomerization domain-like receptors, retinoic acid-inducible gene I-like receptors, and TLR signaling pathways. Conversely, at the late stage, IFIs, IL1, and MMP3 were significantly upregulated, while complement proteins were downregulated. Biomarkers such as TLR2 may underscore the host's antiviral defense response to HSV-1 in the periodontal environment.

conclusionsThe present study identified several HGF proteins associated with periodontitis following HSV-1 infection, providing an analytical framework for determining the host's anti-viral defense response to antagonize HSV-1 infection in periodontal tissues.

Indexed as

CytokinesFibroblastsGingivaHerpes SimplexHerpesvirus 1, HumanPeriodontitisBiomarkersCells, CulturedHumansInterleukin-6Matrix Metalloproteinase 2Matrix Metalloproteinase 3ProteomeProteomicsTandem Mass SpectrometryToll-Like Receptor 2BiomarkersCytokinesInterleukin-6Matrix Metalloproteinase 2Matrix Metalloproteinase 3ProteomeToll-Like Receptor 2cytokineHSV‐1infectionperiodontitis

Identifiers

PMID41353774
PMCPMC13364949

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.