Evidence map›Paper›PMID 41353742›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026

Intraoperative Identification and Stimulation of the Ansa Cervicalis Nerve Plexus.

Connie C Ma, Kyle Mannion, Michael C Topf, Sarah L Rohde, Alexander J Langerman, James L Netterviell, Robert Sinard, David Zealear, Yike Li, Alan R Schwartz and 4 more

Abstract read
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Connie C MaDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-0969-3611
Kyle MannionDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9391-1791
Michael C TopfDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-1022-4417
Sarah L RohdeDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-4353-5745
Alexander J LangermanDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-0866-463X
James L NetterviellDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-7282-8769
Robert SinardDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9348-2165
David ZealearDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9363-8377
Yike LiDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-8465-130X
Alan R SchwartzDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9222-3751
Silvana BellottoHospital Vila Nova Star, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5562-7191
Carol LeeAnn WellsDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Katherine E EstesDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
David T KentDepartment of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-8183-5269

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Augmented Reality to Guide Head and Neck Cancer SurgeryK08CA293255 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael Topf · 2024 to 2026
$645k
NCI NIH HHS K08 CA293255NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

objectiveQuantify the anatomic variation of the ansa cervicalis and evaluate neurostimulation of the infrahyoid musculature. STUDY

designIntraoperative physiology study.

settingTertiary referral center.

methodsAdult patients undergoing lateral neck dissection including level IV for head and neck cancer were recruited. Ansa cervicalis plexus branches were documented during surgical dissection. In a subset of participants, an electrode was placed on branches of the common sternothyroid trunk innervating the sternothyroid and sternohyoid muscles. Hyolaryngeal excursion with neurostimulation was recorded.

resultsMeasurements were collected from 39 of 50 participants. Reasons for intraoperative exclusion included significant radiation fibrosis (n = 4), nodal disease burden (n = 3), and surgeon preference (n = 4). The mean lengths of the common sternothyroid trunk and sternothyroid branch were 37.6 ± 15.0 mm and 20.4 ± 8.1 mm, respectively. Their respective mean diameters were 2.1 ± 0.7 mm and 1.5 ± 0.5 mm. The distance from sternothyroid branch muscle insertion to the sternum varied substantially (12.8 ± 14.8 mm). Nine patients underwent neurostimulation of the common sternothyroid trunk. The amplitude of first observed muscle contraction was 0.35 ± 0.18 mA and maximal was 0.57 ± 0.40 mA, during which the hyolaryngeal complex descended by 13.6 ± 4.6 mm. In patients with anatomy amenable to neurostimulation of other nerve branches, stimulation of the common sternothyroid trunk produced the greatest hyolaryngeal descent (P < .05).

conclusionThe minor variability observed in ansa cervicalis nerve diameter across patients and branches supports the feasibility of a standardized electrode design for an implantable neurostimulation device. Stimulation of the common sternothyroid trunk resulted in the greatest hyolaryngeal descent, highlighting its value as a potential neuromodulation target.

Indexed as

Cervical PlexusElectric StimulationHead and Neck NeoplasmsNeck DissectionNeck MusclesAdultAgedFemaleHumansMaleMiddle Agedansa cervicalisneuromodulationneurostimulationobstructive sleep apnea

Identifiers

PMID41353742
PMCPMC12860186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.