Electrochemical selective C6 Thio-/Selenocyantion of tetrahydroquinolines and C4 thiocyanation of anilines.

Yu-Fang Tan, Dan Yang, Zhi Guan, Yan-Hong He

Abstract read

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Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Yu-Fang TanKey Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.

Dan YangKey Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.

Zhi GuanKey Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. guanzhi@swu.edu.cn.

Yan-Hong HeKey Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. heyh@swu.edu.cn.

Funding

National Natural Science Foundation of China 22378334National Natural Science Foundation of China 22477103

6 · The paper itself

Abstract

A novel and environmentally benign electrochemical method has been developed for the regioselective C6 thiocyanation of tetrahydroquinolines using potassium thiocyanate (KSCN) as an inexpensive and readily available thiocyano source. This transition-metal-free and oxidant-free protocol proceeds under mild conditions, enabling efficient construction of C(sp²)-SCN bonds. Utilizing TEMPO as a redox mediator, the reaction affords 6-thiocyanato-tetrahydroquinoline derivatives in moderate to good yields. The protocol is also applicable to the C4 thiocyanation of anilines and the C6 selenocyanation of tetrahydroquinolines. The method demonstrates excellent regioselectivity, high atom economy, broad substrate scope, and good functional group compatibility, providing a practical approach to a range of valuable thiocyanated and selenocyanated derivatives.

Indexed as

Aniline CompoundsElectrochemical TechniquesQuinolinesThiocyanatesOxidation-Reduction1,2,3,4-tetrahydroquinolineanilineAniline CompoundsQuinolinesthiocyanateThiocyanatesElectrochemicalSelenocyanationTetrahydroquinolinesThiocyanation

Identifiers

PMID41353699

DOI10.1007/s11030-025-11425-x

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.