Evidence map›Paper›PMID 41353698›Full record

ArticleMolecular diversity2026

Design, synthesis, and mechanistic evaluation of alepterolic acid derivatives incorporating indole and piperazine moieties as anticancer agents targeting breast cancer.

Lian Ma, Yanchun Sun, Binbin Zhang, Zixuan Tong, Yating Jia, Peixin Wang, Bingbing Ou, Jianguo Cao, Guozheng Huang

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lian MaDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.
Yanchun SunDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.
Binbin ZhangCollege of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.
Zixuan TongDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.
Yating JiaCollege of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.
Peixin WangCollege of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.
Bingbing OuDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.
Jianguo CaoCollege of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China. cao101@shnu.edu.cn.
Guozheng HuangDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China. guozheng.huang@ahut.edu.cn.

Funding

Science and Technology Project of Ma'anshan City No. 2022KN-11
6 · The paper itself

Abstract

Breast cancer represents the most prevalent malignancy worldwide and persists as the principal contributor to cancer mortality in women. Natural origins supply invaluable bioactive constituents demonstrating potential antitumor properties with improved safety. In this investigation, a sequence of alepterolic acid derivatives bearing indole or indazole functionality coupled with piperazine substituents were conceived and synthesized. Validation of molecular structures employed ESI-MS, ¹H NMR, and ¹³C NMR spectroscopic techniques. Experimental outcomes established that derivatives 14n and 14t manifested IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsDrug DesignIndolesPiperazinesApoptosisCell ProliferationFemaleHumansMCF-7 CellsMembrane Potential, MitochondrialNaphthalenesPentetic AcidPiperazineReactive Oxygen SpeciesStructure-Activity Relationshipalepterolic acidAntineoplastic AgentsindoleIndolesNaphthalenesPentetic AcidPiperazinePiperazinesReactive Oxygen SpeciesAlepterolic acidBreast cancerIndolePiperazineStructural modification

Identifiers

PMID41353698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.