ArticleEuropean journal of medical research2025
Association of the endothelial activation and stress index with cognitive function in older adults: a cross-sectional study with machine learning.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Endothelial Dysfunction and Erectile Dysfunction: Evidence From EASIX Score in NHANES 2001-2004.American journal of men's healthArticle
- Article
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5 authors.
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Abstract
backgroundAge-associated memory impairment (AAMI) is a predementia state linked to endothelial dysfunction. The endothelial activation and stress index (EASIX) quantifies endothelial injury, yet its association with cognitive function remains unvalidated in population studies. This study aimed to evaluate the relationship between EASIX and cognitive performance.
methodsData from adults aged ≥ 60 years in the NHANES 2011-2014 were analyzed. Multiple linear regression assessed associations between EASIX and cognitive function scores. LASSO regression selected variables, and six machine learning models (e.g., Random Forest and XGBoost) were developed. SHAP values interpreted feature importance.
resultsAmong 2,763 participants, EASIX showed a significant negative correlation with all cognitive scores (P < 0.05). The ElasticNet model outperformed other models. SHAP analysis identified EASIX as one of the top four influential variables, with cognitive function levels demonstrating a declining trend as EASIX score increased, particularly among older adults.
conclusionsEASIX is significantly negatively associated with cognitive function, especially in advanced age. Although the cross-sectional design precludes causal inference, it shows promise as a blood-based biomarker for early screening and risk assessment of cognitive decline, supporting its potential clinical utility.
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