Evidence map›Paper›PMID 41353511›Full record

ReviewAnnals of biomedical engineering2026

Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.

Yong Liu, Di Gong, Kuanrong Dang, Junhong Guo, Yijia Huang, Weihua Yang, Jiantao Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong Liu *Jinan University, Guangdong, China.ORCID http://orcid.org/0000-0002-2784-4911
Di Gong *Jinan University, Guangdong, China.
Kuanrong Dang *Jinan University, Guangdong, China.
Junhong GuoJinan University, Guangdong, China.
Yijia HuangShenzhen Eye Medical Center, Shenzhen Eye Hospital, Southern Medical University, Shenzhen, China.
Weihua YangShenzhen Eye Medical Center, Shenzhen Eye Hospital, Southern Medical University, Shenzhen, China. benben0606@139.com.
Jiantao WangJinan University, Guangdong, China. wangjiantao65@126.com.

Funding

Basic Research Project of Shenzhen JCYJ20240813152617023Sanming Project of Medicine in Shenzhen SZSM202311012Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties SZGSP014Shenzhen Key Medical Discipline Construction Fund SZXK037Shenzhen Science and Technology Program JCYJ20220818103207015
6 · The paper itself

Abstract

High myopia (HM) is a vision-threatening ocular disorder characterized by excessive axial elongation. While previous studies have primarily focused on structural and functional impairments in the posterior segment-including the optic nerve, posterior sclera, and macular region-recent evidence indicates that adaptive remodeling also occurs in anterior segment structures, such as the cornea, anterior sclera, and lens. In this review, we examine the molecular mechanisms underlying anterior segment remodeling in high myopia, investigate the associated biomechanical alterations using ex vivo and in vivo measurement techniques, and analyze the interrelationships among these changes. Furthermore, we highlight how multimodal imaging technologies, when integrated with artificial intelligence algorithms, enable the quantitative assessment of biomechanical parameters. These advances may contribute to improved prediction of myopia progression, risk stratification for associated complications, and the development of personalized therapeutic strategies. Finally, we discuss the current challenges and translational bottlenecks in this area.

Indexed as

Anterior Eye SegmentMyopiaAnimalsBiomechanical PhenomenaHumansAI-driven multimodal imagingAnterior segmentBiomechanical remodelingHigh myopiaMolecular tissue

Identifiers

PMID41353511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.