Evidence map›Paper›PMID 41353500›Full record

ArticleScientific reports2025

Breastfeeding protects against malnutrition and growth failure in children with microcephaly associated with congenital Zika syndrome.

Deysiane Santiago da Silva, Nivia Maria Rodrigues Arrais, Letícia Karla Cunha Dos Santos, Suamy Sales Barbosa, Ádila Danielly Souza Costa, Márcia Marilia Gomes Dantas Lopes, Karla Danielly da Silva Ribeiro

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Deysiane Santiago da SilvaHealth Sciences Center, Nutritionist. Postgraduate Program in Nutrition, Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0009-0008-4985-8071
Nivia Maria Rodrigues ArraisDoctor and Professor. Department of Pediatrics. Health Sciences Center, Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0000-0002-4919-311X
Letícia Karla Cunha Dos SantosNutritionist. Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0009-0004-6556-0487
Suamy Sales BarbosaDepartment of Nutrition, Health Sciences Center, Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0000-0002-2525-3931
Ádila Danielly Souza CostaNutritionist. Dr. João Machado General Hospital, Natal, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0000-0002-1893-1490
Márcia Marilia Gomes Dantas LopesNutritionist and Professor. Department of Nutrition, Health Sciences Center. Postgraduate Program in Applied Sciences to Women's Health, Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0000-0002-2251-5967
Karla Danielly da Silva RibeiroNutritionist and Professor. Department of Nutrition, Health Sciences Center. Postgraduate Program in Nutrition, Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Brazil. karla.danielly@ufrn.br.ORCID http://orcid.org/0000-0002-0011-576X

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação Norte-Rio-Grandense de Pesquisa e Cultura - FUNPEC 003/2020
6 · The paper itself

Abstract

Congenital Zika Virus Syndrome (CZS) impacts children's physical and cognitive development, and it is still unknown how breastfeeding protects their growth. This 5-year cohort study followed children with CZS microcephaly to analyze the relationship between breastfeeding practices and the presence of malnutrition and growth failure at 6, 24, 36, 48 and 60 months. Breastfeeding was evaluated by Exclusive breastfeeding (EBF) under six months, EBF for the first two days after birth (EBF2D), long-term EBF (LTEBF, when above 3 months), short-term EBF (STEBF, when below 3 months), and continued breastfeeding 12-24 months (CBF). Malnutrition was determined by z-scores weight-for-age, length/height-for-age, and weight-for-length/height, and the presence of growth failure. Associations were explored using covariate-adjusted logistic regression equations. Malnutrition increased throughout childhood. The LTEBF reduced the risk of underweight and stunting at 24 months simultaneously (RR = 0.163; 95% CI = 0.03-0.996; p = 0.049); and children who received CBF had a lower risk of growth failure between 6 and 24 months (RR = 0.034; 95% CI = 0.0-0.52; p = 0.015). Breast milk was a protective factor against malnutrition for children with CZS, reducing the risk of underweight and stunting at 24 months and the risk of growth failure between 6 and 24 months.

Indexed as

Breast FeedingGrowth DisordersMalnutritionMicrocephalyZika Virus InfectionChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornMaleZika VirusBreastfedFailure to thriveLactationMicrolissencephaliesStuntingUnderweight

Identifiers

PMID41353500
PMCPMC12796230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.