Evidence map›Paper›PMID 41353463›Full record

ArticleScientific reports2025

Impact of accelerometer epoch summary measure on associations between physical activity and all-cause mortality in Whitehall II and UK Biobank.

Henrik R Eckmann, Cameron Razieh, Ian Meneghel Danilevicz, Sam Vidil, Sebastien Chastin, Lauren B Sherar, Bjørge H Hansen, Paddy C Dempsey, Séverine Sabia, Alex V Rowlands

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Henrik R EckmannDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, LE5 4PW, UK. hdre1@le.ac.uk.
Cameron RaziehDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, LE5 4PW, UK.
Ian Meneghel DanileviczEpidemiology of Ageing and Neurodegenerative Diseases, Universite Paris Cité, INSERM, U1153, CRESS, 10 Avenue de Verdun, 75010, Paris, France.
Sam VidilEpidemiology of Ageing and Neurodegenerative Diseases, Universite Paris Cité, INSERM, U1153, CRESS, 10 Avenue de Verdun, 75010, Paris, France.
Sebastien ChastinSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK.
Lauren B SherarNational Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and The University of Leicester, Leicester, LE5 4PW, UK.
Bjørge H HansenDepartment of Sport Science and Physical Education, University of Agder, P.O. Box 422, 4604, Kristiansand, Norway.
Paddy C DempseyDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, LE5 4PW, UK.
Séverine SabiaEpidemiology of Ageing and Neurodegenerative Diseases, Universite Paris Cité, INSERM, U1153, CRESS, 10 Avenue de Verdun, 75010, Paris, France.
Alex V RowlandsDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, LE5 4PW, UK.

Funding

HORIZON EUROPE Marie Sklodowska-Curie Actions 101072993UK Research and Innovation EP/X042464/1
6 · The paper itself

Abstract

Accelerometer data are commonly reduced into epoch summary measures (ESMs) for analysis, e.g. ENMO (Euclidean Norm Minus One), MAD (Mean Amplitude Deviation), MIMS (Monitor Independent Movement Summary) or Counts. We compared associations with all-cause mortality of the volume and intensity of physical activity when derived from those four measures in the Whitehall II and UK Biobank cohorts. Volume (Average Acceleration, AvAcc) and intensity (Intensity Gradient, IG) were derived from each ESM. Associations with mortality were estimated using Cox models. 3733 (25.1% female, median age 68.3 years) and 89,848 (56.4% female, 63.5 years) participants were included from Whitehall II and UK Biobank, respectively. Median (IQR) follow-up was 11.0 (10.7, 11.3) and 8.0 (7.5, 8.5) years, with 563 (15.1%) and 3656 (4.1%) deaths. Associations with mortality were largely consistent between ESMs with the lowest mortality risk for those high (above the median) in both AvAcc and IG (Whitehall: HR = 0.59-0.68; Biobank: 0.55-0.61, reference: low/low), and IG associated with lower mortality risk, irrespective of AvAcc. AvAcc was associated with lower mortality irrespective of IG in Biobank only. In conclusion, associations of AvAcc and IG with mortality are broadly consistent across common ESMs, supporting comparability of activity-health findings across studies using different ESMs.

Indexed as

AccelerometryExerciseMortalityAgedBiological Specimen BanksFemaleHumansMaleMiddle AgedProportional Hazards ModelsUK BiobankUnited KingdomAccelerometryAverage accelerationEpoch summary measureIntensity gradientMortalityPhysical activity

Identifiers

PMID41353463
PMCPMC12780095

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