Evidence map›Paper›PMID 41353440›Full record

ArticleCell death & disease2025

CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway.

Li Yang, Xiang Li, Yun Zhu, Yu Zhang, Zheqi Liu, Chengzhong Lin, Canhua Jiang, Yu-Xiong Su, Tong Ji, Yang Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li Yang *Department of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiang Li *Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Yun Zhu *Department of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yu ZhangDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zheqi LiuDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Chengzhong LinDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Canhua JiangDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China.
Yu-Xiong SuDivision of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0001-7143-3370
Tong JiDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yang WangDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. wang.yang2@zs-hospital.sh.cn.ORCID http://orcid.org/0009-0007-7377-5092
Jun GaoShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China. gaojun@fudan.edu.cn.ORCID http://orcid.org/0000-0002-5925-537X
Jinhai YeDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. yejinhai@fudan.edu.cn.ORCID http://orcid.org/0000-0002-3789-551X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81973308National Natural Science Foundation of China (National Science Foundation of China) 82473200National Natural Science Foundation of China (National Science Foundation of China) No. 82303457
6 · The paper itself

Abstract

Casein kinase 1δ (CK1δ, encoded by casein kinase 1 delta) (CSNK1D) is a serine/threonine protein kinase closely associated with cancer development. However, the biological functions of CSNK1D in head and neck squamous cell carcinoma (HNSCC) remain unclear. This study identifies CSNK1D as a previously unrecognized yet crucial regulator in the progression of HNSCC. CSNK1D expression levels were upregulated in tumor tissues and the up-regulation was positively correlated with poor survival in patients with HNSCC. Moreover, CSNK1D selectively bound SHH and PTCH1, and regulated the stability of the CSNK1D-SHH-PTCH1 complex to control the GLI1-BCL2 axis, leading to the downstream activation of the hedgehog pathway. SB-203580 could target and inhibit CSNK1D, offering new perspectives for the clinical treatment of HNSCC. Overall, CSNK1D is underscored as a vital oncogenic driver and promising therapeutic target for HNSCC.

Indexed as

Casein Kinase IdeltaHead and Neck NeoplasmsHedgehog ProteinsPatched-1 ReceptorSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeSignal TransductionZinc Finger Protein GLI1Casein Kinase IdeltaHedgehog ProteinsPatched-1 ReceptorPTCH1 protein, humanSHH protein, humanZinc Finger Protein GLI1

Identifiers

PMID41353440
PMCPMC12779978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.