Infection with Helicobacter pylori and the age at onset of coeliac disease in the "HUNT4" survey.

Kjetil K Melby, Rebecka Hjort, Knut E A Lundin, Eivind Ness-Jensen

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Kjetil K MelbyDepartment of Microbiology, Oslo University Hospital, N-0407, Oslo, Norway. k.k.melby@medisin.uio.no.

Rebecka HjortHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.

Knut E A LundinNorwegian Coeliac Disease Research Centre, Faculty of Medicine, University of Oslo, Oslo, Norway.

Eivind Ness-JensenHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to determine whether H. pylori or its antigens affect the age at which coeliac disease (CeD) was diagnosed. Participants over 20 years old from the HUNT4 survey were screened for CeD by measuring serum immunoglobulin A and immunoglobulin G antibodies against transglutaminase-2. H. pylori status was defined by detecting H. pylori-specific immunoglobulin G.

resultsH. pylori + participants had a mean age of 62.3 years, compared to 54.8 years for negative participants. In those with previously undiagnosed CeD (n = 43), higher antibody levels against GroEL were associated with an older age at sampling (67.2 years for GroEL-positive vs. 50.8 years for negative). Smaller age differences were noted for gGT (6.0 years), UreA (8.6 years), and HpcC (6.4 years), while vacA and cagA showed only minor differences. Participants with CeD and H. pylori + were older than those who were H. pylori-. The presence of antigens such as GroEL, gGT, and UreA appeared to be associated with this age difference. Aside from H. pylori infection in childhood, a cohort effect of H. pylori infection may partly explain the differences.

Indexed as

Celiac DiseaseHelicobacter InfectionsHelicobacter pyloriAdultAgedAge of OnsetAntibodies, BacterialAntigens, BacterialBacterial ProteinsChaperonin 60FemaleHumansImmunoglobulin AImmunoglobulin GMaleMiddle AgedAntibodies, BacterialAntigens, BacterialBacterial ProteinsChaperonin 60Immunoglobulin AImmunoglobulin GProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesAge at onsetCoeliac diseaseHelicobacter pyloriH.pylori antigensHUNT4 survey

Identifiers

PMID41353374

DOI10.1186/s13104-025-07594-5

PMCPMC12784621

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