Evidence map›Paper›PMID 41353368›Full record

ArticleBMC psychiatry2025

Autobiographical narratives in major depression: changes in memory specificity during outpatient psychodynamic psychotherapy.

Magdalena Lutz, Jonathan R Nowak, Ivo Dönnhoff, Hans-Christoph Friederich, Valentin Terhoeven, Christoph Nikendei

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Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Magdalena Lutz *Department of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany.
Jonathan R Nowak *Department of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany. jonathan.nowak@med.uni-heidelberg.de.
Ivo DönnhoffDepartment of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany.
Hans-Christoph FriederichDepartment of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany.
Valentin TerhoevenDepartment of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany.
Christoph NikendeiDepartment of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that patients with depression recall fewer specific autobiographical memories, a phenomenon known as overgeneral autobiographical memory (OGM). OGM refers to the retrieval of categorical memories (repeated events) and extended memories (events lasting more than 24 h), rather than specific, single-event recollections. This pattern has been linked to dysfunctional emotion regulation and childhood trauma. While most research has used the Autobiographical Memory Test (AMT) to assess OGM, such standardized cue-word paradigms are limited in capturing how autobiographical memories unfold in real-life psychotherapeutic settings. This study introduces a novel methodology to assess autobiographical memories as they naturally emerge during videotaped psychodynamic psychotherapy sessions.

methodsWe analyzed videotapes of the first and 40th psychodynamic psychotherapy sessions of 55 patients with major depression. Therapist questions served as prompts for autobiographical narratives, which were rated for specificity and overgeneralization (extended, categorical). We also examined the role of adverse childhood experiences (ACEs) in changes to memory specificity during therapy.

resultsLinear regression analysis showed a significant time × memory-type × ACE interaction. No significant changes were observed for categorical or extended memories. In contrast, for specific memories, higher ACE scores predicted fewer specific memories at baseline but greater increases in specificity from session 1 to 40.

conclusionsThis study demonstrates the feasibility of assessing autobiographical memory specificity directly within psychodynamic psychotherapy sessions. The proposed methodology provides an ecologically valid alternative to traditional lab-based assessments of autobiographical memory and can be applied in the naturalistic context of real-life therapeutic interactions. Our findings suggest a potential improvement in autobiographical memory specificity during psychodynamic psychotherapy - particularly among individuals with higher ACE scores - that may be reliably assessed using this novel approach. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Major Depressive DisorderMemory, EpisodicMental RecallPsychotherapy, PsychodynamicAdultAdverse Childhood ExperiencesFemaleHumansMaleMiddle AgedNarrationOutpatientsAdverse childhood experiencesAutobiographical memory testDepressionOvergeneral autobiographical memoryPsychotherapy

Identifiers

PMID41353368
PMCPMC12690838

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