ReviewJournal of assisted reproduction and genetics2026
The uterine and vaginal microbiome in assisted reproductive technologies: implications for maternal and offspring outcomes.
Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- The Possibility and Characteristics of Senescence-Related Changes in Reproductive Tissues Such as the Ovary, Oviduct, and Uterus.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAssisted reproductive technologies (ART) have provided significant advancements in infertility treatment. Despite this, ART-conceived pregnancies are also associated with higher risks for adverse maternal and offspring outcomes. Recent evidence highlights the role of the reproductive tract microbiome (mainly the vaginal and endometrial microbiome) in implantation success and gestational physiology. The purpose of this review is to summarize the state of knowledge pertaining to the content, function, and disruption of the uterine and vaginal microbiome in ART contexts and to consider the adverse effects of changing the microbiome on maternal health, pregnancy outcomes, and development of progeny.
methodsA narrative synthesis of the literature covering the period 2005-2025 was undertaken using the PubMed, Scopus, and CINAHL databases. Articles addressing microbiome changes associated with ART and reproductive outcomes were included.
resultsART procedures such as vaginal antisepsis, oocyte retrieval, embryo transfers, hormone stimulation, and use of prophylactic antibiotics have caused observable disruptions to the reproductive tract microbiome. The loss of Lactobacillus dominance and the development of dysbiosis are linked with lower implantation rates, a higher incidence of gestational disorders, such as preeclampsia and gestational diabetes, a heavy risk of preterm delivery, and an increased risk of adverse neonatal outcomes, such as altered immune development and developmental delay. Furthermore, newer alternatives including probiotics, individual microbiome testing, and multi-omic platforms show promise, but are limited by variability in clinical approaches and a lack of empirical backing.
conclusionThe uterine and vaginal microbiome profoundly impact ART outcomes by modulating implantation, immune tolerance, and fetal development. Integrating microbiome-informed diagnostics and therapies into fertility treatments offers a new frontier in precision reproductive medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.