Evidence map›Paper›PMID 41353279›Full record

ArticleNature communications2025

Urea use drives niche separation between dominant marine ammonia oxidizing archaea.

Joerdis Stuehrenberg, Katharina Kitzinger, Jan N von Arx, Jon S Graf, Gaute Lavik, Sten Littmann, Jana Milucka, William D Orsi, Sina Schorn, Daan R Speth and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Joerdis Stuehrenberg *Max Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0009-0006-2168-1003
Katharina Kitzinger *Max Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0000-0001-7382-7103
Jan N von ArxMax Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0009-0001-6656-7195
Jon S GrafMax Planck Institute for Marine Microbiology, Bremen, Germany.
Gaute LavikMax Planck Institute for Marine Microbiology, Bremen, Germany.
Sten LittmannMax Planck Institute for Marine Microbiology, Bremen, Germany.
Jana MiluckaMax Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0000-0003-4013-230X
William D OrsiDepartment of Earth and Environmental Sciences, Palaeontology & Geobiology, Ludwig-Maximilian-University, Munich, Germany.ORCID http://orcid.org/0000-0002-4094-5637
Sina SchornMax Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0000-0002-1655-1304
Daan R SpethMax Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0000-0002-2361-5935
Aurèle VuilleminDepartment of Earth and Environmental Sciences, Palaeontology & Geobiology, Ludwig-Maximilian-University, Munich, Germany.ORCID http://orcid.org/0000-0002-7724-8931
Siqi WuMax Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0000-0002-0928-7787
Hannah K MarchantMax Planck Institute for Marine Microbiology, Bremen, Germany. hmarchan@mpi-bremen.de.ORCID http://orcid.org/0000-0002-1482-9165
Marcel M M KuypersMax Planck Institute for Marine Microbiology, Bremen, Germany.ORCID http://orcid.org/0000-0001-7991-5091

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) EXC-2077-390741603
6 · The paper itself

Abstract

Ammonia-oxidizing archaea (AOA) are among the most abundant microorganisms in the ocean and play a critical role in marine nitrogen cycling. Recently, urea has been shown to serve as an additional substrate for marine AOA, with substantial urea use in the ammonium-depleted open-ocean. Yet, the mechanisms that control urea use and potentially maintain high AOA abundances remain unclear. Here, we investigate urea and ammonia use by AOA in three contrasting marine environments, from coastal, ammonium-rich to open-ocean, ammonium-poor waters. Our combined results indicate that distinct substrate utilization strategies of Nitrosopumilus and Nitrosopelagicus control their environmental distribution. The more coastal AOA genus, Nitrosopumilus, primarily uses ammonium. In contrast, enhanced urea utilization in ammonium-limited waters is linked to the activity and growth of Nitrosopelagicus. Thus, the use of urea, and potentially other organic-N compounds by Nitrosopelagicus plays a major role in fueling open-ocean nitrification and sustaining primary productivity in these vast regions.

Indexed as

AmmoniaArchaeaSeawaterUreaAmmonium CompoundsEcosystemNitrificationOceans and SeasOxidation-ReductionAmmoniaAmmonium CompoundsUrea

Identifiers

PMID41353279
PMCPMC12686405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.