ArticleScientific reports2025
α-Mangostin, a safe and natural product as a candidate skin-whitening agent.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
A-Mangostin is the predominant xanthone found in the pericarp of mangosteen. It has been scientifically proven to possess anti-proliferative and apoptotic properties against different types of human cancer cells. In Asia, α-mangostin is widely used as a natural ingredient in cosmetic and medicinal products, particularly for treating acne and skin issues.Our objective was to evaluate the impact of α-mangostin on microphthalmia-associated transcription factor (MITF) and pigmentation related genes, and to explore the mechanism of α-mangostin on ultraviolet (UV)-B or forskolin (FSK)-induced pigmentation in cultured skin. We designed subgroups to evaluate the expression level of pigmentation related genes in cultured skin and B16F10 cells by α-mangostin and the melanin production level induced by UVB or FSK, respectively. The results showed that 40 µM α-mangostin could significantly reduce the melanin content in UVB-stimulated hair follicles treated with H
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