Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Kyle J PopovichSection of Infectious Diseases, Rush University Medical Center/Cook County Health, Chicago, IL, USA. Kyle_Popovich@rush.edu.
Evan S SnitkinDepartment of Microbiology and Immunology, University of Michigan Medical Center, Ann Arbor, MI, USA. esnitkin@umich.edu.ORCID http://orcid.org/0000-0001-8409-278X
Funding
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Institutional Career Development Core (Chapter 1)KL2TR002387 · NCATS · UNIVERSITY OF CHICAGO · PI ERIC C BEYER, Lisa L Barnes · 2017 to 2026
$7.6M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
The Michigan Infectious Disease Genomics (MIDGE) CenterU19AI181767 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM, SNITKIN, EVAN · 2024 to 2024
$6.2M
Mitigating COVID-19 transmission in U.S. jailsR01AI146079 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI POPOVICH, KYLE JEANNE · 2020 to 2025
$3.5M
Genomic Epidemiology of Methicillin-Resistant Staphylococcus aureus in JailR01AI114688 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI POPOVICH, KYLE JEANNE · 2015 to 2019
$1.8M
Genome-driven identification of patient and bacterial drivers of resistance to novel beta-lactam/beta-lactamase inhibitor combination therapiesF31AI186288 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GONTJES, KYLE JAMES · 2024 to 2025
$84k
NCATS NIH HHS KL2 TR002387NHGRI NIH HHS T32 HG000040NIAID NIH HHS F31 AI186288NIAID NIH HHS R01 AI114688NIAID NIH HHS R01 AI146079NIAID NIH HHS T32 AI007528NIAID NIH HHS U19 AI181767U.S. Department of Health & Human Services | National Institutes of Health (NIH) F31-AI186288U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI114688U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI146079U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32AI007528U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32HG000040U.S. Department of Health & Human Services | National Institutes of Health (NIH) U19AI181767
6 · The paper itself
Abstract
Jails have been hypothesized to be hotspots for the spread of methicillin-resistant Staphylococcus aureus (MRSA). We integrate genomic and epidemiologic data to investigate USA300 MRSA transmission in Cook County Jail (Illinois, USA) and its connected communities. A genome-wide association study of 308 jail isolates from 2015-2018 revealed a plasmid encoding the ermC clindamycin/erythromycin resistance gene was associated with a 6-fold increased odds of MRSA genetic linkages among detainees. Additionally, 52% of jail-onset MRSA infections carried this plasmid compared to 14% of intake colonization isolates, supporting its role in MRSA spread in the jail. Extending our analysis to 774 isolates from a local healthcare system from 2011-2014, the ermC-carrying plasmid was also associated with MRSA transmission in the larger community and was enriched among former jail detainees and those with related isolates to recently incarcerated cases. Lastly, topical clindamycin exposure before MRSA infection was associated with ermC plasmid presence in both settings, but exposure prevalence was higher in jail versus community cases (7.5% vs. 0.9%), suggesting antibiotic use in the jail may have created a favorable environment for the spread of ermC-carrying strains. These findings highlight the impact of antibiotic use in jails on antibiotic resistance in both jails and their surrounding communities.
Indexed as
Drug Resistance, BacterialJailsMethicillin-Resistant Staphylococcus aureusPlasmidsStaphylococcal InfectionsAdultAnti-Bacterial AgentsClindamycinFemaleGenome-Wide Association StudyHumansMaleMicrobial Sensitivity TestsMiddle AgedPrisonersAnti-Bacterial AgentsClindamycin
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities. · full record | OpenQuestion