ArticleNature communications2025
Direct deoxygenative arylation of saccharides via phosphorus-assisted C-OH bond activation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Benzodithiolane-Enabled C─O Bond Activation for Deoxygenative Functionalization of Carbohydrates and Nucleosides.Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Aryl C-glycosides are privileged scaffolds in drug discovery, biochemical research, and materials science. Established methods for their synthesis typically involve radical cross-coupling of saccharides. However, the glycosyl donors required in these methods encounter longstanding challenges, including instability and the need for prefunctionalization at the anomeric position. Herein, we report a highly efficient radical cross-coupling approach in which the native hydroxyl group on saccharides is activated in situ by a phosphorus reagent, enabling C - C bond formation with aryl iodides to afford a broad range of aryl C-glycosides. A combination of Zn and I
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Registered trials
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