ArticleNature communications2025
Pangenome analyses of tea plants reveal structural variations driving gene expression alterations and agronomic trait diversification.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Elucidating and exploring specialised plant metabolism through a pangenomic and pantranscriptomic lens.The Plant journal : for cell and molecular biology · 2026Review
- Comparative Genomics of the TeaInternational journal of molecular sciences · 2026Article
- Morphological and Chemical Characterization of a Novel Wild Tea Plant Resource with Naturally Low Caffeine and High Theobromine from Guangxi Province, China.Plants (Basel, Switzerland) · 2026Article
- Evolutionary and pan-genomic analysis of theFrontiers in plant science · 2026Article
- Pangenome-driven discovery and comparative genomics of glycosyltransferase genes inFrontiers in plant science · 2026Article
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21 authors.
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Abstract
Tea plants, which are among the world's most economically important beverage crops, exhibit extensive genetic diversity and are rich in secondary metabolites. While structural variations (SVs) drive phenotypic diversification, their regulatory roles in transcriptional networks and agronomic traits remain underexplored in this perennial crop. Here, we construct a pangenome from 22 representative tea accessions and their wild relatives. Genomic SV analysis reveals that 22% of the gene promoters contain variants influencing flavonoid, amino acid, and terpenoid biosynthesis. Population SV analysis of 275 tea accessions reveals three haplotypes in the ANS3 promoter, with Hap1, containing a 192 bp insertion, predominantly found in wild relatives but largely lost in modern cultivars. This insertion increases CtANS3 expression and anthocyanin content in wild relatives. Additionally, a 159 bp insertion in the CtLRR1 promoter reduces resistance to Colletotrichum gloeosporioides in wild relatives. Our findings underscore SVs as pivotal regulators of flavor differentiation and adaptive evolution during tea plant domestication.
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