Evidence map›Paper›PMID 41352538›Full record

ArticleVirologica Sinica2025

A decreased proportion of naïve MAIT cells is associated with the incomplete immune reconstitution in antiretroviral therapy-treated HIV-1 patients.

Jie Jia, Hong-Yi Zheng, Yu Zhao, Kai-Cheng Gao, Deshenyue Kong, Danfeng Lu, Ji-Qun Yang, Jun-Hong Mao, Xiuwen Wang, Kun-Hua Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jie JiaResearch Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming Medical University, Kunming, 650500, China.
Hong-Yi ZhengState Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.
Yu ZhaoResearch Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming Medical University, Kunming, 650500, China.
Kai-Cheng GaoResearch Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming Medical University, Kunming, 650500, China.
Deshenyue KongNHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming 650032, China.
Danfeng LuNHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming 650032, China.
Ji-Qun YangThird People's Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City, Kunming 650041, China.
Jun-Hong MaoNHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming 650032, China.
Xiuwen WangBeijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Kun-Hua WangNHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming 650032, China; School of Life Science, Yunnan University, Kunming 650500, China.
Bin SuBeijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. Electronic address: binsu@ccmu.edu.cn.
Jian-Hua WangGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address: wang_jianhua@gibh.ac.cn.
Yong-Tang ZhengState Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China. Electronic address: zhengyt@mail.kiz.ac.cn.
Yi-Qun KuangResearch Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming Medical University, Kunming, 650500, China. Electronic address: kuangyiqun@kmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incomplete immune reconstitution occurs in 10%-40% of antiretroviral therapy (ART)-treated human immunodeficiency virus (HIV) patients. This subset of immunological non-responders (INRs) has yet to undergo a comprehensive analysis of immunological profiles, and no definitive cytological diagnosis has been established. In this study, we comparatively analyzed the immunological profiles of INRs, immunological responders (IRs), and healthy control individuals (HCs) via single-cell RNA sequencing (scRNA-seq) and single-cell T-cell receptor (TCR) repertoire sequencing of peripheral blood mononuclear cells (PBMCs), and identified a relatively small population of mucosal-associated invariant T (MAIT) cells in INRs. This finding was recapitulated in rhesus macaques infected with simian immunodeficiency virus (SIV). Specifically, the population of the naïve MAIT cell subtype was significantly lower in INRs than in IRs, and the majority of MAIT cells were CD8

Indexed as

Anti-Retroviral AgentsHIV-1HIV InfectionsImmune ReconstitutionMucosal-Associated Invariant T CellsAdultAnimalsAntiretroviral Therapy, Highly ActiveCD8-Positive T-LymphocytesFemaleHumansLeukocytes, MononuclearMacaca mulattaMaleMiddle AgedReceptors, Antigen, T-CellAnti-Retroviral AgentsReceptors, Antigen, T-CellHuman immunodeficiency virus (HIV)Immune reconstitutionImmunological responseSingle-cell RNA sequencingT-cell receptor repertoire

Identifiers

PMID41352538
PMCPMC12826970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.