Evidence map›Paper›PMID 41352454›Full record

ArticleTransplantation and cellular therapy2026

Optimizing Patient Selection for Reduced Nonrelapse Mortality After Reduced-Intensity Conditioning: A CIBMTR Analysis.

Yu Akahoshi, Nelli Bejanyan, Hideki Nakasone, Machiko Kusuda, Yuma Tada, Emiko Sakaida, Yoshiko Atsuta, Yoshinobu Kanda, Takahiro Fukuda

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Article in Transplantation and cellular therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yu AkahoshiDivision of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: akahoshiu@gmail.com.
Nelli BejanyanDepartment of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida.
Hideki NakasoneDivision of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan; Division of Emerging Medicine for Integrated Therapeutics (EMIT), Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
Machiko KusudaDivision of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Yuma TadaDepartment of Hematology, Osaka International Cancer Institute, Osaka, Japan.
Emiko SakaidaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Aichi, Japan; Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Aichi, Japan.
Yoshinobu KandaDivision of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Takahiro FukudaDivision of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NTP INFORMATION SYSTEMS SUPPORT27305C0011 · NIEHS · Z-TECH CORPORATION · 2007 to 2009
$4.3M
PROVIDE RABBITS, RATS, MICE, HAMSTERS, GERBILS, GUINEA PIGS27307C0011 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$500k
NCI NIH HHS U24 CA076518NIEHS NIH HHS 27305C0011NIEHS NIH HHS 27307C0011NIEHS NIH HHS 27398C0011
6 · The paper itself

Abstract

backgroundReduced-intensity conditioning (RIC) is generally associated with lower nonrelapse mortality (NRM) but higher relapse risk compared to myeloablative conditioning (MAC) in allogeneic hematopoietic cell transplantation (HCT). The Risk assessment for the Intensity of Conditioning regimen in Elderly patients (RICE) score, developed using a large Japanese cohort, was designed to identify patients likely to benefit from reduced NRM with RIC. It is calculated based on three factors: advanced age, high comorbidities, and use of umbilical cord blood donor. PURPOSE: In this study, we evaluated the applicability of the RICE score in a Western population using a publicly available CIBMTR dataset. STUDY

designThis study included 2595 patients aged 40 to 65 years with AML and MDS who underwent their first HCT between 2009 and 2015. The primary endpoint was NRM, stratified by conditioning intensity and RICE score.

resultsAmong patients with a low RICE score, MAC was associated with similar NRM (HR, 0.86; 95% CI, 0.70 to 1.06; P = .150) but lower relapse, resulting in improved disease-free survival (DFS). In contrast, among patients with a high RICE score, NRM was significantly lower with RIC compared to MAC (HR, 0.69; 95% CI, 0.48 to 0.99; P = .048), while DFS was similar due to a higher relapse rate with RIC.

conclusionThis study provides external validation of the RICE score in a Western cohort and suggests its potential to inform conditioning-intensity selection based on individual patient characteristics. This simple, data-driven tool may help accurately assess the risk of NRM associated with conditioning intensity and improve transplant outcomes across diverse populations.

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteMyelodysplastic SyndromesPatient SelectionTransplantation ConditioningAdultAgedFemaleHumansMaleMiddle AgedConditioning intensityNonrelapse mortalityPersonalized medicine

Identifiers

PMID41352454
PMCPMC12698115

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