Evidence map›Paper›PMID 41352164›Full record

SynthesisEnvironment international2026

Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis.

Zhebin Yu, Irene Fontes Marques, Simon Kebede Merid, Kimberley Burrows, Ana Goncalves Soares, Andrei Pyko, Mikael Ögren, Göran Pershagen, Johanna Lepeule, Norun Hjertager Krog and 23 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Zhebin YuInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Irene Fontes MarquesThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Simon Kebede MeridDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Kimberley BurrowsCentre for Academic Child Health, Population Health Sciences, Bristol Medical School at the University of Bristol, Bristol, UK; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Ana Goncalves SoaresPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Andrei PykoInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Sweden.
Mikael ÖgrenOccupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Johanna LepeuleUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France.
Norun Hjertager KrogDepartment of Air Quality and Noise, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Gunn Marit AasvangDepartment of Air Quality and Noise, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Michelle S W KustersISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Maria ForasterPHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain.
Mariona BustamanteISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Púbica, Madrid, Spain.
Miriam LeskienInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Ahmed ElhakeemPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Médical Faculty, Ludwig-Maximilians-Universit ̈ at München, Munich, Germany; Munich Heart Alliance, German Center for Cardiovascular Health (DZHK e.V., partner-site Munich), Munich, Germany.
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Ayoung JeongSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Medea ImbodenSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Nicole Probst-HenschSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Roel VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Mark NieuwenhuijsenISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Púbica, Madrid, Spain.
Mònica GuxensISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, the Netherlands; CIBER Epidemiología y Salud Púbica, Madrid, Spain; ICREA, Barcelona, Spain.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; German Center for Child and Adolescent Health (DZKJ), Munich, Germany; German Center for Lung Research (DZL), Munich, Germany.
Vincent W J JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Stephanie J LondonDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Erik MelénDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Olena GruzievaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Sweden. Electronic address: olena.gruzieva@ki.se.

Funding

GENETIC AND ENVIRONMENTAL FACTORS IN CHILDHOOD RESPIRATORY HEALTHZ01ES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1996 to 2008
$537k
Intramural NIH HHS Z01 ES049019
6 · The paper itself

Abstract

Road traffic noise exposure has been associated with multiple adverse outcomes in epidemiological studies. However, the underlying biological mechanisms remain unclear. The aim of this study was to investigate the association between road traffic noise exposure and cord blood and child blood DNA methylation (DNAm). Data from six European studies (BAMSE, Generation R, HELIX, INMA, LISA, PIAMA) were used to perform the discovery epigenome-wide meta-analysis. Prenatal, infancy, and recent road traffic noise exposure was assessed at the residential addresses. Blood DNAm was measured using the Illumina 450 K or EPIC arrays. To identify differentially methylated positions (DMPs), we fitted robust linear regression models for each cohort, and the results were subsequently meta-analyzed. Differentially methylated regions (DMRs) were identified using Comb-p and DMRcate. Findings were then looked-up in the independent ALSPAC cohort, in which noise was measured categorically. A total of 1477 newborns with DNAm data in cord blood, and 1129 and 2065 with DNAm in child blood (age 4-6 and age 8-10 years, respectively) were included in the discovery meta-analysis. We did not observe genome-wide significant (False Discovery Rate (FDR) < 0.05) DMPs associated with road traffic noise exposure. However, 46 DMPs reached suggestive significance (P < 1 × 10

Indexed as

DNA MethylationEnvironmental ExposureEpigenomeNoise, TransportationChildChild, PreschoolEpigenesis, GeneticFemaleFetal BloodHumansInfant, NewbornMaleBirth cohortsDNA methylationEpigenome-wide association analysisRoad traffic noise

Identifiers

PMID41352164
PMCPMC12829588

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.