Evidence map›Paper›PMID 41351919›Full record

ArticleEuropean journal of medicinal chemistry2026

Development of activators for SERCA2a for heart failure treatments.

Marzena Brinkmann, Tsung-Yun Kent Wong, Osha Roopnarine, Samantha L Yuen, Kaja Berg, Razvan L Cornea, Robyn T Rebbeck, David D Thomas, Courtney C Aldrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marzena BrinkmannDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street S.E., Minneapolis, 55455, MN, USA.
Tsung-Yun Kent WongDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street S.E., Minneapolis, 55455, MN, USA.
Osha RoopnarineDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street S.E., Minneapolis, 55455, MN, USA.
Samantha L YuenDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street S.E., Minneapolis, 55455, MN, USA.
Kaja BergDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street S.E., Minneapolis, 55455, MN, USA.
Razvan L CorneaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street S.E., Minneapolis, 55455, MN, USA.
Robyn T RebbeckDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street S.E., Minneapolis, 55455, MN, USA. Electronic address: rrebbeck@umn.edu.
David D ThomasDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street S.E., Minneapolis, 55455, MN, USA. Electronic address: ddt@umn.edu.
Courtney C AldrichDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street S.E., Minneapolis, 55455, MN, USA. Electronic address: aldri015@umn.edu.

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Structural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2M
Skeletal muscle protein structural dynamics and function drive applications to drug discoveryR01AR082533 · NIAMS · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE, Robyn T Rebbeck · 2023 to 2026
$2.5M
NHLBI NIH HHS R01 HL139065NIAMS NIH HHS R01 AR082533NIAMS NIH HHS T32 AR007612
6 · The paper itself

Abstract

The sarco/endoplasmic reticulum Ca

Indexed as

Drug DevelopmentEnzyme ActivatorsHeart FailureSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesAnimalsCalciumDose-Response Relationship, DrugHumansMolecular StructureStructure-Activity RelationshipCalciumEnzyme ActivatorsSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesActivatorsADMETATPase activityCalcium uptakeHeart failureSARSERCA2a

Identifiers

PMID41351919
PMCPMC12900291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.