ReviewCell biology and toxicology2025
The role of FIS1 and its post-translational modifications in diseases and health damage caused by environmental pollution.
Review in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dynamic imbalance of mitochondria-associated ER membranes in cardiovascular disease: mechanisms, context dependence and therapeutic potential.Frontiers in cell and developmental biology · 2026Review
- Integrating multi-omics, EWAS, and reverse network toxicology to explore environmental pollutant risks in erectile dysfunction.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mitochondrial fission protein 1 (FIS1) is present in the cytoplasm and can be transported to the outer mitochondrial membrane. It can interact with DRP1 (Dynamin-Related Protein 1) to mediate mitochondrial fission and fusion, and most of the studies on FIS1 have centered on FIS1-DRP1 mitochondrial fission. However, more and more studies are now showing that FIS1 is not only involved in mitochondrial fission, but also plays a role in mitophagy, peroxisomal dynamics, and lysosomes. Post-translational modification (PTM) of proteins enables proteins to perform distinct functions and exhibit diverse properties, thereby creating multiple possibilities for many proteins. The post-translational modification of FIS1 protein is associated with the occurrence of many diseases. Environmental pollution has become a serious public health problem that affects people's health. The role of FIS1 in human health caused by environmental pollutants is worth in-depth study and exploration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.