ArticleMolecular biology reports2025
Stathmin-mediated autophagy drives the differentiation of dermal fibroblast into myofibroblast under TGFβ1 stimulation.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Dual Roles of Autophagy in Endometrial Fibrosis and Its Implications in Age-Related Reproductive Dysfunction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Stathmin in human health and diseases: from cytoskeletal dynamics to clinical implications.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe differentiation of skin dermal fibroblast into myofibroblast is a critical process in tissue repair and granulation tissue formation, directly affecting the progression of wound healing. While autophagy has been implicated in regulating dermal fibroblast differentiation during wound repair, the underlying molecular mechanisms remain incompletely defined. METHODS AND
resultsIn the current study, Transforming Growth Factor-Beta 1 (TGFβ1) was applied to induce the differentiation of skin dermal fibroblast into myofibroblast. We demonstrated that the activation of autophagy by TGFβ1 stimulation and p38 Mitogen-Activated Protein Kinase (p38/MAPK) coincided with an increase in stathmin expression. Moreover, the inhibition of p38/MAPK, transfection of small interfering RNA of stathmin or beclin1 significantly suppressed autophagy and differentiation of skin dermal fibroblast into myofibroblast. In contrast, p38/MAPK activation or stathmin overexpression, led to autophagy induction and fibroblast differentiation under TGFβ1 stimulation.
conclusionsOur findings elucidate a novel role of stathmin in regulating differentiation of skin dermal fibroblast into myofibroblast, and suggest its potential as a therapeutic target for clinical wound healing interventions.
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Registered trials
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