Evidence map›Paper›PMID 41351593›Full record

ArticleJACC. Case reports2026

One-Stop Transcatheter Pulmonary and Tricuspid Valve Replacement for Carcinoid Heart Disease Treatment.

Nicolas Veas, Fernando J Verdugo, Jaime Álvarez, Daniel Springmuller, Camila Bontá, Fernanda Esteves, Vinicius Esteves, Manuel Méndez

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolas VeasCardiology Unit, Clinica BUPA Santiago, Santiago, Chile. Electronic address: nicoveas@gmail.com.
Fernando J VerdugoCardiology Unit, Clinica BUPA Santiago, Santiago, Chile. Electronic address: https://twitter.com/fjverdugo1.
Jaime ÁlvarezCardiology Unit, Clinica BUPA Santiago, Santiago, Chile.
Daniel SpringmullerPediatric Cardiology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
Camila BontáEchocardiography Laboratory, Hospital del Salvador, Santiago, Chile.
Fernanda EstevesUniversity Hospitals Harrington Heart & Vascular Institute, Cleveland, Ohio, USA.
Vinicius EstevesDepartment of Interventional Cardiology, Rede D'Or São Luiz, Rio de Janeiro, Brazil. Electronic address: https://twitter.com/vinesteves.
Manuel MéndezCardiology Unit, Clinica BUPA Santiago, Santiago, Chile. Electronic address: https://twitter.com/manumlesser.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarcinoid heart disease is a complex consequence of functional neuroendocrine tumors, characterized by progressive thickening and degeneration of the right-sided valvular apparatus, leading to valvular and heart failure. Management is challenging, requiring multidisciplinary considerations regarding tumor disease management, heart failure pharmacotherapy, and heart valve replacement in individuals with acceptable performance status. CASE SUMMARY: We present a case of a middle-aged man with a history of metastatic neuroendocrine tumor receiving biweekly octreotide therapy. He presented with constitutional syndrome and right-sided heart failure signs. Cardiac imaging revealed significant tricuspid and pulmonary regurgitation. The patient was a poor surgical candidate; consequently, after multimodal cardiac imaging assessment, alternative 1-stop transcatheter pulmonary and tricuspid replacement was planned and performed. DISCUSSION: Patients with symptomatic carcinoid heart disease require comprehensive multidisciplinary evaluation. For high-risk patients with multivalvular disease, transcatheter valve replacements provide a feasible and less invasive alternative to standard surgical replacement. TAKE-HOME MESSAGES: One-stop transcatheter valvular interventions are a feasible therapeutic alternative to surgical replacement in patients with symptomatic carcinoid heart disease and suitable anatomy. Multimodal cardiac imaging is crucial for preprocedural assessment and the performance of transcatheter right-sided heart valve interventions.

Indexed as

carcinoid heart diseasepulmonary valve insufficiencypulmonary valve regurgitationtranscatheter valve replacementtricuspid valve insufficiencytricuspid valve regurgitation

Identifiers

PMID41351593
PMCPMC12926188

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.