Evidence map›Paper›PMID 41351493›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self-Assembly within Highly Crowded Microgel Pastes.

Elif Narbay, Abbygail Caine, Sanika Pandit, Gabrielle Montgomery, Marion Harper, E Daniel Cárdenas-Vásquez, Hatte Hamilton, Megan Hicks, Daniel Mattar, Kyle Choy and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elif NarbayDale E. and Sarah Ann Fowler School of Engineering, Chapman University, Orange, CA, 92866, USA.
Abbygail CaineSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
Sanika PanditSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
Gabrielle MontgomerySchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
Marion HarperSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
E Daniel Cárdenas-VásquezDale E. and Sarah Ann Fowler School of Engineering, Chapman University, Orange, CA, 92866, USA.
Hatte HamiltonSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
Megan HicksSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
Daniel MattarDale E. and Sarah Ann Fowler School of Engineering, Chapman University, Orange, CA, 92866, USA.
Kyle ChoySchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
Marco BisoffiSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.
L Andrew LyonSchmid College of Science and Technology, Chapman University, Orange, CA, 92866, USA.ORCID https://orcid.org/0000-0001-7828-7345

Funding

Chapman UniversitySchmid College
6 · The paper itself

Abstract

The fabrication of a new class of biomimetic biomaterials is reported using nanostructured microgel pastes formed from "overpacked" assemblies of ultrasoft poly(N-isopropyl acrylamide-co-acrylic acid) microgels and their composites with collagen. Despite the solid-like nature of microgel pastes, collagen fibrillogenesis is robust and rapid, with a 3D collagen network forming throughout the paste volume. Structural organization within the composite is interrogated via a suite of microscopy methods, while rheological characterization provides insight into the static and dynamic mechanical properties of the materials. Long-range fibrillogenesis is enabled by local crowding, dynamics, and spatial reconfigurability of pastes at the colloidal length-scale, and by liquid-liquid phase separation during fibril formation, features that mimic the dynamic reorganization of natural extracellular matrix. In vitro 3D cell culture studies illustrate that the paste is non-toxic, permeable to nutrients, and permissive to cell invasion, while collagen fibers present sites for cell attachment and spreading. Together, these results suggest the platform's potential in the development of tissue scaffolds that mimic crowded and dynamic biological tissues. These materials address the need for new approaches to biomaterials that offer dynamic, bio-integrative environments for tissue healing and regenerative medicine via synthetic and spatial control from the polymer to the macroscopic length scales.

Indexed as

CollagenMicrogelsAcrylic ResinsAnimalsBiocompatible MaterialsBiomimetic MaterialsHumansRheologyTissue ScaffoldsAcrylic ResinsBiocompatible MaterialsCollagenMicrogelsextracellular matrixmicrogelsmimicrymolecular crowdingtissue scaffold

Identifiers

PMID41351493
PMCPMC12902624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.