Association Between Atherogenic Index of Plasma and Patients With Acute Ischemic Stroke Receiving Intravenous Thrombolysis: A Retrospective Cohort, Multi-Center Study.

Rongrong Shao, Zhengyang Wang

Abstract readMulticenter Study

In one paragraph

Article in Revista de neurologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Rongrong ShaoDepartment of Neurology, Shanghai Fifth People's Hospital Affiliated to Fudan University, 200240 Shanghai, China.

Zhengyang WangDepartment of Neurology, Taizhou Clinical Medical School of Nanjing Medical University, Jiangsu Taizhou People's Hospital, 225300 Taizhou, Jiangsu, China.

Funding

Minhang District natural science research project 2022MHZ039

6 · The paper itself

Abstract

objectivesThere are inherent risks associated with intravenous thrombolysis (IVT) therapy in patients with acute ischemic stroke (AIS). The atherogenic index of plasma (AIP), defined as log (triglyceride [TG]/high-density lipoprotein cholesterol [HDL-C]), has recently been associated with the prognosis. We aimed to gauge AIP prognostic value in AIS patients receiving IVT.

methodsWe retrospectively collected data from 183 AIS patients who underwent IVT. We grouped modified Rankin Scale scores of 0-2 and 3-6 as good and poor outcomes at 1 year, respectively. Multivariate logistic regression, receiver operating characteristic (ROC) curve and restricted cubic spline (RCS) analyses were used to investigate the underlying link between the AIP and 1-year functional outcomes.

resultsIn this study, 67 patients (36.6%) exhibited poor 1-year outcomes. An optimal AIP cut-off of 0.188 was used to divide the patients into low and high AIP levels. Our results showed that continuous AIP (odds ratio [OR] = 25.10, 95% confidence interval [CI]: 4.86-129.68,

conclusionsHigh AIP may offer potential value as a novel target for predicting 1-year outcomes in patients receiving IVT.

Indexed as

AtherosclerosisCholesterol, HDLFibrinolytic AgentsIschemic StrokeThrombolytic TherapyTriglyceridesAdministration, IntravenousAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesROC CurveCholesterol, HDLFibrinolytic AgentsTriglyceridesacute ischemic strokeatherogenic index of plasmaintravenous thrombolysisrisk factor

Identifiers

PMID41351390

DOI10.31083/RN40923

PMCPMC12681004

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