Observational studyBMC cardiovascular disorders2025
Relationship of endothelial activation and stress index on concurrent acute kidney injury in patients with heart failure during intensive care unit: a competing risk model analysis.
Observational study in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Independent and Incremental Prognostic Value of the Endothelial Activation and Stress Index Beyond the GRACE Score for Predicting 1-Year Mortality in Patients with Non-ST-Segment Elevation Myocardial Infarction.Medicina (Kaunas, Lithuania) · 2026Article
- Association between Endothelial Activation and Stress Index and mortality in patients with coronary heart disease at intensive care unit: a retrospective cohort study.Journal of thoracic disease · 2026Article
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4 authors.
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Abstract
objectiveTo investigate the association between endothelial activation and stress index (EASIX) and acute kidney injury (AKI) in heart failure (HF) patients.
methodsThe study utilized data from the MIMIC-IV database. EASIX was log-transformed to address its right-skewed distribution. The association of log EASIX with AKI and in-hospital mortality was assessed using logistic regression and Kaplan-Meier curves, and its discriminating performance was evaluated by the area under the receiver operating characteristic curve. A competing risk model was further employed, considering AKI occurrence as a primary event and in-hospital mortality as a competing event.
resultsAmong 4,740 included HF patients, 53.143% were experiencing AKI. Log EASIX was an independent risk factor for AKI across three adjusted regression models (Model 1: OR = 3.398, 95%CI: 2.909-3.980; Model 2: OR = 5.788, 95%CI: 4.965-6.771; Model 3: OR = 2.331, 95%CI: 1.956-2.786), and demonstrated moderate discriminating performance (AUC = 0.704). Additionally, high log EASIX was associated with an increase in in-hospital mortality (p < 0.05). Multivariable competing risk analyses exhibited an independent influence of log EASIX on AKI (p < 0.05).
conclusionHigh log EASIX levels are associated with an increased risk of AKI in HF patients. In clinical practice, log EASIX, being simple to operate and readily accessible, may serve as an effective tool for the early identification of high-risk patients and help to develop individualized treatment strategies.
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