ArticleEuropean journal of medical research2025
The impact of asparaginase phenotype-related single nucleotide polymorphisms on prognosis in pediatric B-cell precursor acute lymphoblastic leukemia.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a significant hematological malignancy and asparaginase plays a significant role in the treatment of BCP-ALL. However, the prognostic value of asparaginase phenotype-related single nucleotide polymorphisms (SNPs) in BCP-ALL remains unclear.
methodsHere, we examined clinical characteristics, genetic mutations, asparaginase phenotype-related SNPs (ADSL (793-49A > C), NFATC2 (2722 + 12367 T > A), PNPLA3 (444C > G), and SOD2 (47A > G)) and treatment outcomes in a retrospective cohort of 356 newly diagnosed BCP-ALL patients.
resultsKaplan-Meier survival analysis of relapse-free survival (RFS) identified five significant risk factors: age ≥ 10 years, white blood cell count ≥ 50 × 10
conclusionsThese findings underscore the importance of asparaginase phenotype-related SNP, ADSL (793-49A > C), in personalized treatment strategies based on genetic profiling and clinical parameters, potentially enhancing therapeutic efficacy and patient outcomes in pediatric BCP-ALL.
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