Evidence map›Paper›PMID 41350935›Full record

SynthesisBone marrow transplantation2026

Efficacy of eltrombopag for treatment of thrombocytopenia in the setting of allogeneic hematopoietic cell transplantation: a systematic review and meta-analysis.

Arni Kumar, Arin Singh, Tea Reljic, Madiha Iqbal, Razan Mohty, Hemant Murthy, Taiga Nishihori, Ricardo Parrondo, Ernesto Ayala, Vivek Roy and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Bone marrow transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arni KumarJudy Genshaft Honors College, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-3326-2141
Arin SinghCollege of Arts and Sciences, University of South Florida, Tampa, FL, USA.
Tea ReljicMorsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID 0000-0003-2029-6753
Madiha IqbalDivision of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-6752-5440
Razan MohtyDivision of Hematology-Oncology and O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-0189-8233
Hemant MurthyDivision of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0003-4534-4248
Taiga NishihoriDepartment of Blood and Marrow Transplantation and Cellular Immunotherapy Program, Moffitt Cancer Center, Tampa, FL, USA.ORCID 0000-0002-2621-7924
Ricardo ParrondoDivision of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-9314-9933
Ernesto AyalaDivision of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA.
Vivek RoyDivision of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-5950-4620
Mahmoud AljurfBlood and Marrow Transplantation Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.ORCID 0000-0003-3942-7370
Mohamed A Kharfan-DabajaDivision of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA. KharfanDabaja.Mohamed@mayo.edu.ORCID 0000-0001-7394-5185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombocytopenia following an allogeneic hematopoietic cell transplant (allo-HCT) is a potentially serious complication, and the efficacy of eltrombopag, a thrombopoietin receptor agonist, in this context is unclear due to inconsistent findings. Additionally, other post-allograft outcomes in eltrombopag treated patients such as transfusion independence, overall survival (OS), and non-relapse mortality have not been systematically reviewed. The aim of this systematic review/meta-analysis (SR/MA) is to evaluate the efficacy of eltrombopag in allo-HCT-induced thrombocytopenia by analyzing data from 16 eligible studies. Pooled rate of response for platelets counts achieving >30 × 10

Indexed as

BenzoatesHematopoietic Stem Cell TransplantationHydrazinesPyrazolesThrombocytopeniaAllograftsHumansMaleTransplantation, HomologousBenzoateseltrombopagHydrazinesPyrazoles

Identifiers

PMID41350935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.