Evidence map›Paper›PMID 41350787›Full record

Observational studySurgical endoscopy2026

Surgical efficiency, safety, and quality of life among four various approaches for T1 stage papillary thyroid carcinoma: a prospective cohort study.

Tianfeng Xu, Xun Zheng, Yuanyuan Fan, Guang Yang, Anping Su, Xiaofei Wang, Wenchuang Walter Hu, Tao Wei

Abstract readObservational StudyComparative Study
PubMed Publisher
In one paragraph

Observational study in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianfeng Xu *Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Xun Zheng *Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Yuanyuan FanDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Guang YangDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Anping SuDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Xiaofei WangDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Wenchuang Walter HuPrecision Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Tao WeiDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China. surgeonwei5776@163.com.

Funding

the "Qimingxing" Research Fund for Young Talents of West China Hospital No.HXQMX0105
6 · The paper itself

Abstract

objectiveThis study aims to comprehensively evaluate surgical efficiency and quality of life (QoL) differences among Conventional open thyroidectomy (COT), gasless endoscopic thyroidectomy trans-axillary approach (GETTA), transoral endoscopic thyroidectomy vestibular approach (TOETVA), and endoscopic thyroidectomy via bilateral-areolar approach (ETBAA) in T1 papillary thyroid carcinoma (T1-PTC) patients. STUDY

designProspective observational cohort study.

settingTertiary academic center.

methods463 female patients with T1-PTC were stratified into four cohorts: GETTA (n = 122), TOETVA (n = 108), COT (n = 128), and ETBAA (n = 105). Perioperative time periods were divided into five parts for analysis. Level VI lymph node dissection was routinely performed, and the yield is reported. QoL was assessed using Voice Impairment Score (VIS), Swallowing Impairment Score (SIS), Scar Cosmesis Assessment and Rating (SCAR-Q), European Organization for Research and Treatment of Cancer QoL Questionnaire-Core 30 (EORTC QLQ-C30), and Symptom Checklist-90 (SCL-90). Longitudinal QoL trends were evaluated during postoperative recovery.

resultsSignificant intergroup disparities were observed in surgical efficiency (P < 0.001); COT demonstrated superior time efficiency. All cohorts experienced transient postoperative QoL declines, with endoscopic groups showing accelerated recovery trajectories in physical, psychological, and cosmetic domains (P < 0.001).

conclusionFour techniques are safe and effective. COT remains the most time-efficient approach, while TOETVA excels in cosmesis. GETTA and ETBAA offer intermediate advantages, combining reasonable efficiency with enhanced recovery profiles. Clinical decision-making should prioritize patient-specific factors, including cosmetic preferences and recovery priorities.

Indexed as

Quality of LifeThyroid Cancer, PapillaryThyroidectomyThyroid NeoplasmsAdultAgedFemaleHumansMiddle AgedNeoplasm StagingProspective StudiesTreatment OutcomeEndoscopic thyroidectomyPapillary thyroid carcinomaQuality of lifeSurgical efficiencySurgical management

Identifiers

PMID41350787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.