ArticleDiabetology & metabolic syndrome2025
Vitamin D supplementation in individuals with type 1 diabetes mellitus (T1DM): a systematic review and meta-analysis focusing on pediatrics.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsType 1 diabetes mellitus (T1DM) is a significant global health concern, particularly among pediatric populations. Emerging evidence suggests that vitamin D supplementation may support glycemic control in individuals with T1DM; however, existing findings are inconsistent, underscoring the need for further investigation.
methodsA comprehensive search of PubMed, Scopus, Cochrane Central, and Web of Science was conducted up to January 2024 to identify relevant English-language randomized controlled trials (RCTs). Risk of bias (ROB) was assessed using the ROB-2 tool. A random-effects model was employed for the meta-analysis using Stata version 17.
resultsFrom 2,744 records screened, twelve RCTs including 485 participants with T1DM were included. Vitamin D supplementation did not significantly impact HbA1c levels (-1.60 [-3.78, 0.57]; I² = 98.07%) but was associated with significant reductions in C-peptide levels (-2.54 [-4.97, -0.11]; I² = 97.03%), fasting blood sugar (FBS) (-1.44 [-2.67, -0.22]; I² = 91.10%), and daily insulin requirements (-0.44 [-0.82, -0.06]; I² = 58.64%). Moreover, 25(OH)D concentrations significantly increased following supplementation (4.19 [3.26, 5.13]; I² = 82.85%). No serious adverse events were reported, supporting the safety of supplementation.
conclusionVitamin D supplementation showed potential benefits in reducing insulin requirements and fasting blood glucose in pediatric T1DM populations. However, its effect on HbA1c remains inconclusive, and the observed reduction in C-peptide levels requires cautious interpretation due to high heterogeneity and possible confounding factors. The certainty of evidence for all outcomes was rated as “low” to “very low” per GRADE assessment. Further large-scale, long-term RCTs are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.