ArticleBMC neurology2025
Association between altered baroreflex control and pain intensity in fibromyalgia.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the sympathetic nervous system dysfunction in fibromyalgia (FM) is unclear. A large series of studies has shown that various abnormalities of the autonomic nervous system are present in fibromyalgia and contribute at least in part to the patients’ complaints and symptoms.
methodsIn FM patients (n = 10) and healthy controls (HC; n = 11) pain intensity (numeric rating scale; NRS), cardiac baroreflex sensitivity (BRS) and muscle sympathetic nerve activity (MSNA) via microneurography at rest and during baroreflex stimulation (lower body negative pressure; LBNP) were assessed.
resultsResting sympathetic activity was higher in FM at baseline (FM patients: 31.1 ± 2.3 bursts/min; HC: 24.3 ± 1.5 bursts/ min, F = 5.736; p = 0.028) and during baroreflex stimulation (F = 5.057; p = 0.044). Pain intensity correlated with MSNA activity (r = 0.760; p = 0.018) and showed a tendency to a negative correlation with BRS (r=-0.641; p = 0.063).
conclusionChanges in the baroreflex circuit with increased sympathetic outflow are associated with increased pain perception in FM.
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