Evidence map›Paper›PMID 41350597›Full record

ArticleScientific reports2025

Lexical meaning is lower dimensional in psychosis.

Claudio Palominos, Frederike Stein, Tilo Kircher, Rosa Ayesa-Arriola, Lena Palaniyappan, Philipp Homan, Iris E Sommer, Wolfram Hinzen

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Claudio PalominosDepartment of Translation & Language Sciences, Universitat Pompeu Fabra, Barcelona, Spain. claudio.palominos@upf.edu.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Rosa Ayesa-ArriolaDepartment of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.
Lena PalaniyappanDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Philipp HomanDepartment of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland.
Iris E SommerDepartment of Neuroscience, University Medical Center Groningen, Antoni Deusinglaan 2, room 117, Groningen, Netherlands.
Wolfram HinzenDepartment of Translation & Language Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

Funding

Carlos III Health Institute CP18/00003European Research Council 101118756German Research Foundation 240413749, 437615541, 437618198, 437618337German Research Foundation 527712970Ministerio de Ciencia e Innovación CNS2022-136110
6 · The paper itself

Abstract

Diverse language models (LMs), including large language models (LLMs) based on deep neural networks, allow us to chart how people organize meanings in speech and how this process breaks down in conditions. Recent evidence has pointed to higher mean semantic similarities between words in people with psychosis, conceptualized as a 'shrunk' (more compressed) semantic space. Based on this, we hypothesized that the dimensionality of the vector spaces as defined by the embeddings of speech samples from LMs would also be easier to reduce in psychosis. To test this, we used principal component analysis (PCA) to calculate different metrics serving as proxies for reducibility, including the number of components needed to reach 90% of variance, and the cumulative variance explained by the first two components. For further exploration, intrinsic dimensionality (ID) was also estimated. Results consistent over datasets in three languages confirmed significantly higher reducibility of the semantic space in psychosis. This result points to the existence of an underlying intrinsic geometry of the space of semantic associations in speech, which may underlie more surface-level measurements such as semantic similarity. It also offers a new foundational approach to speech in mental disorders.

Indexed as

LanguagePsychotic DisordersSemanticsFemaleHumansMaleNeural Networks, ComputerPrincipal Component AnalysisSpeechLanguage modelsPsychosisSchizophreniaSemanticsWord embeddings

Identifiers

PMID41350597
PMCPMC12780149

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.