A novel method for the mechanochemical synthesis of unsymmetrical disulfides using phosphorodithioic acid derivatives.

Mikołaj Walter, Agata Grobelna, Janusz Rachoń, Dariusz Witt, Sebastian Demkowicz

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Mikołaj WalterDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland.

Agata GrobelnaDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland.

Janusz RachońDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland.

Dariusz WittDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland.

Sebastian DemkowiczDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland. sebastian.demkowicz@pg.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we report the efficient synthesis of unsymmetrical disulfides using a mechanochemical ball-milling approach. This research successfully yielded alkyl-alkyl, alkyl-aryl, and aryl-aryl unsymmetrical disulfides without any detectable formation of symmetrical products. Additionally, we eliminated the use of solvent in the reaction mixture and replaced triethylamine with the more environmentally friendly cesium carbonate as a base. These results represent a significant advancement in the modern synthesis of disulfides, which have applications in pharmacology.

Indexed as

DisulfidesMechanochemistrySolvent-free synthesisThiolsVibrational ball mill

Identifiers

PMID41350563

DOI10.1038/s41598-025-29563-5

PMCPMC12770550

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