ArticleDiscover oncology2025
The oncogenic role of lncRNA DSG2-AS1 and its functional link to SGK1 in laryngeal squamous cell carcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- VAV2-associated ncRNA network in the focal adhesion pathway is dysregulated in laryngeal squamous cell carcinoma.Discover oncology · 2026Article
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6 authors.
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Abstract
objectiveLaryngeal squamous cell carcinoma (LSCC) remains a malignancy with rising incidence and poor prognosis. Understanding the molecular biomarkers is critical for improving diagnostic and therapeutic strategies. In this study, the expression levels of serum/glucocorticoid-regulated kinase 1 (SGK1) and the novel long non-coding RNA (lncRNA) Desmoglein-2 Antisense RNA 1 (DSG2-AS1) were assessed in LSCC tissues compared to adjacent normal tissues.
methodsThe gene and protein expression levels were assessed in the LSCC tissues (n = 50) compared to adjacent normal tissues (n = 50) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) technique and western blot analysis, respectively.
resultsResults showed that the SGK1 gene and protein expression levels (p = 0.015 and p < 0.0001, respectively) and lncRNA DSG2-AS1 (p = 0.003) were elevated in cancerous tissues relative to corresponding normal tissues. Notably, a positive correlation was identified between SGK1 and DSG2-AS1 gene expression levels (r = 0.321, p = 0.001).
conclusionThis study is the first to demonstrate concurrent upregulation of SGK1 and DSG2-AS1 in LSCC, as oncogene targets. It showed a potential relationship that may be involved in tumor progression among LSCC patients.
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