SynthesisCalcified tissue international2025
Does the Use of Methylphenidate Affect Bone Health? A Systematic Review and Meta-analysis of Preclinical Studies.
Synthesis in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Methylphenidate (MP) is widely prescribed for attention-deficit/hyperactivity disorder in children and adults. Concerns have emerged regarding its potential effects on bone health, including changes in bone mineral density, fracture risk, and size. However, its effects on skeleton remains controversial. This systematic review and meta-analysis aimed to clarify whether MP administration affects bone health in animal models. Our review was registered with PROSPERO (CRD 42023468466) following PRISMA guidelines. A comprehensive search of MEDLINE, Embase, Scopus, and CINAHL was conducted through May 2025, with no restrictions on year or language. Eight studies from 508 identified articles met the inclusion criteria after full-text screening. These studies compared the effects of different doses of MP on bone morphology, biomechanical properties, microarchitecture, and histomorphometric endpoints in rats' axial and appendicular skeletons. The studies also compared the effects of age at initiation of MP treatment and different durations of MP treatment. Overall, a trend emerged indicating that MP may exert detrimental effects on various bone parameters, particularly in long bones, with age at MP treatment initiation and dose- and duration- dependent responses. Additionally, MP treatment may influence bone tissue directly, through actions on bone cells, and indirectly, through changes in body weight. Meta-analyses revealed significant adverse effects on bone morphology and mechanical properties, especially with higher doses and prolonged exposure. However, the overall risk of bias ranged from unclear to high across included studies, requiring caution in interpretation. The findings emphasize the need for further research into the mechanisms behind MP's impact on bone, including age at MP treatment initiation and treatment duration, dose-response relationships, and sex differences. Better understanding of the metabolic pathways which influence MP's effects on the above endpoints could clarify broader implications of MP use on skeletal health and inform clinical practices.
Indexed as
Identifiers
41350476What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.