Evidence map›Paper›PMID 41350397›Full record

ArticleCommunications biology2025

MicroRNA-mediated neuronal detargeting alters astrocyte cell fate conversion trajectories in vivo.

Hussein Ghazale, Martin Parga Pazos, Sascha Jung, Ke Cao, Lakshmy Vasan, Jack W Hickmott, Linghe Zhang, Cindi M Morshead, Chao Wang, Antonio Del Sol and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hussein GhazaleSunnybrook Research Institute, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-4558-5295
Martin Parga PazosCIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, Derio, Spain.
Sascha JungCIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, Derio, Spain.
Ke CaoSunnybrook Research Institute, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0915-6429
Lakshmy VasanSunnybrook Research Institute, Toronto, ON, Canada.
Jack W HickmottDepartment of Surgery, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3764-1138
Linghe ZhangSunnybrook Research Institute, Toronto, ON, Canada.
Cindi M MorsheadDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Chao WangSunnybrook Research Institute, Toronto, ON, Canada.
Antonio Del Sol *CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, Derio, Spain. antonio.delsol@uni.lu.ORCID http://orcid.org/0000-0002-9926-617X
Carol Schuurmans *Sunnybrook Research Institute, Toronto, ON, Canada. carol.schuurmans@sunnybrook.ca.ORCID http://orcid.org/0000-0003-3567-0058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal reprogramming using adeno-associated viruses with a GFAP mini-promoter offers a promising strategy for astrocyte-to-neuron conversion; however, specificity remains a challenge due to off-target transgene expression in endogenous neurons. To address this issue, here we incorporated microRNA-124 target sequences (124T) into a transcriptional cassette containing the GFAP mini-promoter and Ascl1

Indexed as

AstrocytesCellular ReprogrammingMicroRNAsNeuronsAnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineageMiceBasic Helix-Loop-Helix ProteinsMicroRNAs

Identifiers

PMID41350397
PMCPMC12680653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.