Evidence map›Paper›PMID 41350390›Full record

ArticleNPJ precision oncology2025

Circulating tumor cell and oncosome subtypes in portal and peripheral venous circulations may be used for diagnosis and prognostication of pancreatic cancer.

Stephanie N Shishido, Divya Suresh, Jeremy Mason, Quin Liu, Kenneth Park, Rabindra Watson, Nicholas Nissen, Srinivas Gaddam, Simon K Lo, Stephen Pandol and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephanie N ShishidoConvergent Science Institute for Cancer, Michelson Center, University of Southern California, Los Angeles, CA, USA.
Divya SureshConvergent Science Institute for Cancer, Michelson Center, University of Southern California, Los Angeles, CA, USA.
Jeremy MasonConvergent Science Institute for Cancer, Michelson Center, University of Southern California, Los Angeles, CA, USA.
Quin LiuPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Kenneth ParkPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Rabindra WatsonPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Nicholas NissenPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Srinivas GaddamPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Simon K LoPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Stephen PandolPancreatic and Biliary Diseases Program, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Peter KuhnConvergent Science Institute for Cancer, Michelson Center, University of Southern California, Los Angeles, CA, USA. pkuhn@usc.edu.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
The paradoxical roles of beta hydroxy butyrate in the liver pro-metastatic nicheP01CA233452 · NCI · CEDARS-SINAI MEDICAL CENTER · PI BHOWMICK, NEIL A., LU, SHELLY CHI-LOO · 2020 to 2024
$9.5M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
Predicting Pancreatic Ductal Adenocarcinoma PDAC Through Artificial Intelligence Analysis of Pre Diagnostic CT Images in African AmericansR01CA260955 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO, PANDOL, STEPHEN J. · 2021 to 2025
$4.8M
Multi-modal Liquid Biopsy Early Assessment of Breast Cancer, Pancreatic Cancer, and Multiple MyelomaU01CA285013 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KUHN, PETER · 2023 to 2025
$3.4M
Fully Quantitative Low-Dose, Motion-Resolved Dynamic Contrast-Enhanced MRI in Pancreatic AdenocarcinomaR01EB032801 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Anthony G Christodoulou, Debiao Li · 2022 to 2026
$2.1M
NCI NIH HHS P01 CA233452NCI NIH HHS P01CA233452NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA260955NCI NIH HHS U01 CA285013NCI NIH HHS U01CA285013NIBIB NIH HHS R01 EB032801NIBIB NIH HHS R01EB032801NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01DK108314USC Norris Comprehensive Cancer Center 5P30CA014089-40
6 · The paper itself

Abstract

Pancreatic adenocarcinoma remains one of the most devastating cancers, with limited options for early diagnosis and outcome prediction. To address these gaps, we prospectively characterized circulating tumor cells (CTCs) and oncosomes from both the peripheral (PB) and portal vein (PoVB). A total of 121 blood samples from 39 patients (75 PB, 46 PoVB) undergoing endoscopic ultrasound were profiled using multiplex immunofluorescence and computational algorithms for rare event detection. Rare event counts were significantly elevated in pancreatic cancer patients compared to normal donors (p = 4.71e-10). PoVB yielded greater numbers of epithelial and mesenchymal CTCs compared to PB, suggesting restricted systemic entry, while oncosomes were consistently detected in both compartments. Diagnostic accuracy was highest for PB oncosomes and PoVB CTCs. Importantly, PoVB mesenchymal CTCs correlated with 1-year survival (p = 0.0083), and PB oncosomes predicted poor survival (p = 0.0014). These findings highlight complementary diagnostic and prognostic value of PB oncosomes and PoVB CTCs in pancreatic cancer.

Identifiers

PMID41350390
PMCPMC12706006

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.