ArticleScientific reports2025
A magnetically recoverable Chitosan-Based nanocomposite for simultaneous removal of tetracycline and antibiotic resistance genes from wastewater.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Advancements in Technologies Targeting Horizontal Gene TransferRoutes to Control Drug Resistance Evolution.ACS bio & med chem Au · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
The co-occurrence of tetracycline antibiotics (TCs) (typically 0.1–50 mg/L in hospital wastewater) and antibiotic resistance genes (ARGs) (10⁵-10⁸ copies/mL) in aquatic systems poses serious environmental and public health concerns. This study presents the design and performance of a multifunctional, magnetically retrievable chitosan-carbon quantum dot/ZnFe2O4 nanocomposite (M-Chit/CQD@ZnFe2O4) for the simultaneous removal of TCs and ARGs through synergistic adsorption and visible-light-driven photocatalysis. The unique tri-component architecture integrates: (i) chitosan’s electrostatic DNA-binding capacity, (ii) CQDs’ π-conjugated domains for enhanced TC affinity, and (iii) ZnFe2O4’s dual magnetic recovery and photocatalytic functionality under visible light. The nanocomposite exhibited exceptional tetracycline adsorption capacity (687.4 ± 12.3 mg/g) at pH 7.0 and 25 °C, significantly outperforming conventional materials. Mechanistic studies using DFT calculations and Fe K-edge XANES revealed π-π stacking (binding energy: -9.7 kcal/mol) and Fe³⁺ chelation as dominant adsorption pathways. Efficient removal of tetA gene (98.2 ± 0.7%) was achieved via electrostatic and hydrogen bonding interactions, as confirmed by FTIR and zeta potential analysis. Photocatalytic regeneration under visible light (λ ≥ 420 nm) enabled > 99% degradation of tetracycline and tetA over 20 cycles, maintaining 96.2 ± 1.8% of initial efficiency. Application to real hospital wastewater confirmed the material’s robustness, with tetracycline removal (214.5 ± 23.1 mg/g) outperforming granular activated carbon by 52%, and ARG capture (tetA, sul1, blaCTX-M-15) maintaining > 75% efficiency. Continuous-flow experiments demonstrated scalability (81.3 ± 2.9% TC removal) and magnetic recovery (94%). Toxicity testing showed moderate ecotoxicity (EC₅₀ = 12.7 mg/L for Daphnia magna), within safe operational limits. These findings highlight M-Chit/CQD@ZnFe2O4 as a promising platform for integrated chemical and genetic pollution control in water treatment applications.
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