ArticleScientific reports2025
Combined RP-HILIC for suspect screening of persistent, mobile, and toxic substances in surface water: A case study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Integrated Chemical and Toxicity Screening of Tap Drinking Water across Western Oregon Using Suspect and Nontarget Screening.Environmental science & technology · 2026Article
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Authors and funding
3 authors.
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Abstract
Persistent, Mobile, and Toxic (PMT) and very Persistent and very Mobile (vPvM) substances pose a significant environmental threat due to their widespread distribution, persistence, and potential toxicity. While previous studies have used reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) to extend analyte coverage, this study uniquely integrates a dual-chromatographic approach with multi-sorbent solid phase etration (SPE) and machine-learning-based retention time indices to rigorously minimize false positives and enhance confidence in suspect screening of PMT/vPvM substances. Two independently optimized LC methods (RP and HILIC) were applied in parallel to the same SPE extract to identify potential chromatographic blind spots. We applied this robust framework to systematically screen surface water and wastewater treatment plant (WWTP) effluent across a water catchment in Uppsala, Sweden. The RP and HILIC workflows, applied as independent chromatographic runs, identified 84 compounds after multi-stage filtering (with retention time indices (RTI) correction applied only to the RP data), with 27% and 48% uniquely detected by HILIC and RP, respectively, highlighting analytical blind spots overcome by this integrated approach. Strategic site selection, encompassing upstream rural zones, on-site sewage facilities, and major WWTP discharge points, demonstrated how local land use impacts PMT/vPvM profiles. This comprehensive method provides a powerful tool for environmental monitoring and regulatory surveillance of PMT/vPvM compounds.
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