ArticleCell death discovery2025
Depletion of tryptophanyl-tRNA synthetase and tryptophan accumulation triggers p53-dependent apoptosis.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Sanguinarine activates ATM/ATR-mediated CHK-1 signaling to drive p53-dependent apoptosis in the C. elegans germline.Scientific reports · 2026Article
- Sanguinarine activates ATM/ATR-mediated CHK-1 signaling to drive p53-dependent apoptosis in thebioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Aminoacyl tRNA synthetases (AaRSs) are enzymes that play a role in maintaining translational fidelity by ensuring the accurate loading of amino acids to their cognate tRNAs. Mutations in the AaRSs are linked to diverse human diseases, including neurological disorders and various types of cancer. Among AaRSs, mutations in wars-1, a tryptophanyl tRNA synthetase, have been associated with cancer. Despite the extensive knowledge of WARS-1, there is no comprehensive understanding of its contribution to pathogenesis. In our previous study, we discovered the impact of WARS-1 on genomic integrity. We showed that WARS-1 depletion leads to a significant accumulation of free tryptophan (Trp), resulting in pronounced genomic instability, including the formation of chromatin bridges and micronuclei, and cell cycle arrest. In this study, we demonstrate that wars-1 knockdown induces apoptosis in the germline of C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.