Evidence map›Paper›PMID 41350254›Full record

ArticleNature communications2025

Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines.

Yang Li, Yu Zhou, Mark R Bortolus, Xiaoxuan Zhang, Zhitong Wang, Dezhi Liu, Hannah Le, Oaikhena Z Esezobor, Jie Ni, Qian Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yang Li *National Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun, China.
Yu Zhou *Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China.
Mark R Bortolus *Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Xiaoxuan ZhangDepartment of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.
Zhitong WangDepartment of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.
Dezhi LiuDepartment of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.
Hannah LeAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Oaikhena Z EsezoborAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Jie NiWarshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China.
Qian ZhangDepartment of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.ORCID http://orcid.org/0000-0002-3136-841X
Neil VasdevAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2087-5125
Gui-Juan ChengWarshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China. chengguijuan@cuhk.edu.cn.ORCID http://orcid.org/0000-0002-2818-2235
Chao ZhengAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. chao.zheng@camh.ca.ORCID http://orcid.org/0000-0002-2179-8096
Junkai FuNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun, China. fujk109@nenu.edu.cn.ORCID http://orcid.org/0000-0002-7714-8818

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) CIHR507113Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) DGECR-2025-00486 and RGPIN-2025-06928Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) PDF-568046-2022National Natural Science Foundation of China (National Science Foundation of China) 22173077 and 22422110National Natural Science Foundation of China (National Science Foundation of China) 22371036 and 21971034Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2019A1515011865Natural Science Foundation of Jilin Province (Natural Science Foundation of Jilin Province of China) 20230508107RCShenzhen Science and Technology Innovation Commission RCYX20200714114736199
6 · The paper itself

Abstract

Unprotected β-fluoroamines are important motifs in synthetic chemistry, offering versatility for the development of β-fluorinated nitrogen-containing compounds. Existing methods to these motifs require tedious operations and suffer from low efficiencies, which has prevented their use in biologically active molecules, such as drug discovery and positron emission tomography (PET) radiotracer development. Herein, an iron-catalyzed three-component aminofluorination of alkenes using a hydroxylamine reagent and Et

Indexed as

AlkenesAminesFluorine RadioisotopesIronRadiopharmaceuticalsCatalysisHalogenationPositron-Emission TomographyAlkenesAminesFluorine RadioisotopesIronRadiopharmaceuticals

Identifiers

PMID41350254
PMCPMC12680689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.