Evidence map›Paper›PMID 41350237›Full record

ArticleAnalytical chemistry2025

Rapid Selective Detection of Phosphatidylethanols by Neutral Loss Scans in Tandem Mass Spectrometry to Evaluate Alcohol Consumption.

Muhammad Mujahid Ali, Joseph V Caruso, Lane Bushman, Lucas Ellison, Peter L Anderson, Harmeet Kaur Chohan, Kristina M Brooks, R Graham Cooks

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammad Mujahid AliDepartment of Chemistry, Purdue University, West Lafayette, Indiana47907, United States.
Joseph V CarusoDepartment of Chemistry, Purdue University, West Lafayette, Indiana47907, United States.ORCID 0009-0002-2207-1208
Lane BushmanDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado80045, United States.
Lucas EllisonDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado80045, United States.
Peter L AndersonDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado80045, United States.
Harmeet Kaur ChohanDepartment of Chemistry, Purdue University, West Lafayette, Indiana47907, United States.
Kristina M BrooksDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado80045, United States.
R Graham CooksDepartment of Chemistry, Purdue University, West Lafayette, Indiana47907, United States.ORCID 0000-0002-9581-9603

Funding

Predictive Power of PEth for HIV Prevention in the Long-Acting EraR01AA030483 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI Kristina Marie Brooks · 2022 to 2026
$3.2M
NIAAA NIH HHS R01 AA030483
6 · The paper itself

Abstract

Phosphatidylethanol (PEth) is a highly specific alcohol biomarker with increasing clinical and forensic utility. However, point-of-care (POC) detection in whole blood remains challenging due to complex LC-MS/MS systems, long run times, and poor selectivity in the negative ion mode. This study presents an alternative strategy for PEth detection in the positive-ion mode, enabled by cationization; neutral loss (NL)-based fragmentation and MS

Indexed as

Alcohol DrinkingGlycerophospholipidsTandem Mass SpectrometryBiomarkersHumansBiomarkersGlycerophospholipidsphosphatidylethanol

Identifiers

PMID41350237
PMCPMC13268223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.