Evidence map›Paper›PMID 41349959›Full record

ArticleACS nano2025

Coupling Adoptive Cell Therapy with Boron Neutron Capture Therapy: Using Functional Tumor-Infiltrating Lymphocytes for Tumor Delivery of Boron Carbide Nanoparticles.

Maria Paola Demichelis, Patrizia Sommi, Nicola Romanini, Agustina Portu, Mario Gadan, Silva Bortolussi, Ian Postuma, Alberto Casu, Andrea Falqui, Maria Elisabetta Federica Palamà and 5 more

Abstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maria Paola DemichelisDepartment of Physics "Alessandro Volta", University of Pavia, Via A. Bassi 6, 27100 Pavia, Italy.
Patrizia SommiUnit of Pavia, National Institute of Nuclear Physics (INFN), Via A. Bassi 6, 27100 Pavia, Italy.ORCID 0000-0002-8749-2866
Nicola RomaniniAdvanced Cellular Therapies and Rare Tumors Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Province of Forlì-Cesena, Italy.
Agustina PortuNational Atomic Energy Commission (CNEA), C1429BNP San Martín, Argentina.
Mario GadanNational Atomic Energy Commission (CNEA), C1429BNP San Martín, Argentina.
Silva BortolussiDepartment of Physics "Alessandro Volta", University of Pavia, Via A. Bassi 6, 27100 Pavia, Italy.
Ian PostumaUnit of Pavia, National Institute of Nuclear Physics (INFN), Via A. Bassi 6, 27100 Pavia, Italy.
Alberto CasuDepartment of Physics "Aldo Pontremoli", University of Milan, Via Celoria 16, 20133 Milan, Italy.ORCID 0000-0002-5056-2170
Andrea FalquiDepartment of Physics "Aldo Pontremoli", University of Milan, Via Celoria 16, 20133 Milan, Italy.ORCID 0000-0002-1476-7742
Maria Elisabetta Federica PalamàReact4life, 16152 Genoa, Italy.
Silvia ScaglioneReact4life, 16152 Genoa, Italy.
Francesca TauceriGeneral and Oncological Surgery, Morgagni-Pierantoni Hospital, 47121 Forlì, Italy.
Giovanni PaganelliNuclear Medicine Operative Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Marcella TazzariAdvanced Cellular Therapies and Rare Tumors Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Province of Forlì-Cesena, Italy.ORCID 0000-0002-8112-1773
Umberto Anselmi-TamburiniUnit of Pavia, National Institute of Nuclear Physics (INFN), Via A. Bassi 6, 27100 Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomedicine offers promising strategies for targeted drug delivery, imaging, and molecular-level therapies. However, the clinical translation of nanomedicine has often been hindered by the complex interactions of nanoparticles (NPs) with biological systems. This study investigates a cell-based delivery platform designed to overcome some of these limitations, using clinical-grade tumor-infiltrating lymphocytes (TILs) as biological carriers of boron carbide (B

Indexed as

Boron CompoundsBoron Neutron Capture TherapyImmunotherapy, AdoptiveLymphocytes, Tumor-InfiltratingNanoparticlesHumansJurkat CellsBoron Compoundsadoptive cell therapyBNCTboron carbidenanoparticlestumor-infiltrating lymphocytes

Identifiers

PMID41349959
PMCPMC12752689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.